Seahawks vs. 49ers 2025 Prediction, Odds, Picks - Jan 3

In a battle featuring two teams coming off victories, the Seattle Seahawks (13-3) will play the San Francisco 49ers (12-4). The Seahawks have taken six in a row, the 49ers six in a row. Seattle is a slim favorite (-2.5). The game has an over/under of 48.5 points.

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Seahawks vs. 49ers Odds & Betting Lines

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Seahawks vs. 49ers Prediction & Pick

• Pick ATS: 49ers (+2.5)
  
• Pick OU: Over (48.5)
  
• Prediction: Seahawks 25 - 49ers 23

How to Watch Seattle vs. San Francisco

• Game date: Saturday, January 3, 2026
• Time: 8 p.m. ET
• Venue: Levi's Stadium
• Location: Santa Clara, California
• TV: ABC/ESPN
• Live Boxscore: FOX Sports

Seahawks vs. 49ers Recent Matchups

• San Francisco owns a 4-1 record against Seattle in their last five matchups.
• In their last five head-to-head matchups, San Francisco has scored 129 points versus Seattle, while surrendering only 86 points.

Seattle Betting Info

• Seattle is 11-5-0 against the spread this season.
• The Seahawks have been favored by 2.5 points or more 10 times this season, and covered the spread in seven of those contests.
• Seattle games this year have gone over the total in nine out of 16 opportunities (56.2%).
• The Seahawks have compiled a 12-1 record in games they played as moneyline favorite (winning 92.3% of those games).
• The Seahawks have an implied win probability, based on the moneyline, of 59.7%.

Seahawks Stats

Seattle's Key Players

Offense

• Jaxon Smith-Njigba has brought in 113 passes (fourth in the NFL) on 155 targets for 1,709 total yards (first in the NFL) and 10 touchdowns. He is averaging 7.1 catches and 106.8 yards per game through 16 games played.
• Sam Darnold has 3,850 passing yards (fifth in the NFL), 25 touchdowns (seventh in the NFL) and 14 interceptions this year. He has completed 67.2% of his attempts, averaging 240.6 yards per game and 8.5 per attempt.
• Kenneth Walker III's output on the ground this season includes 930 yards and five TDs. He's averaging 58.1 yards per game and 4.5 per attempt (19th in the NFL).
• Walker has 27 receptions, 246 yards and zero TDs through the air.
• Zach Charbonnet has run for 656 yards, averaging 43.7 yards per game and scoring 11 touchdowns.

Defense

• On defense, Ernest Jones has 121 tackles, 4.0 TFL, 0.5 sacks, and five interceptions in 2025. His tackle total leads the Seahawks.
• Demarcus Lawrence has 52 tackles, 11.0 TFL, and six sacks this season.
• This season, Drake Thomas has put up 3.5 sacks (fifth on the Seahawks) in addition to his 10.0 TFL and 83 tackles.
• Leonard Williams has 62 tackles, 9.0 TFL, seven sacks, and one pass defended.

San Francisco Betting Info

• San Francisco has compiled an 11-5-0 record against the spread this year.
• The 49ers have covered the spread once this year when underdogs by 2.5 points or more (in four chances).
• This season, 10 San Francisco games have gone over the point total.
• This season, the 49ers have won one out of the four games in which they've been the underdog.
• The moneyline for this contest implies a 44.6% chance of a victory for the 49ers.

49ers Stats

San Francisco's Key Players

Offense

• This year through 16 games, Christian McCaffrey has racked up 1,179 rushing yards (leading the 49ers and eighth in the NFL) and scored 10 rushing touchdowns. He averages 73.7 yards per game and 3.9 per carry (37th in the NFL).
• McCaffrey has also been a part of the passing game with 890 yards (55.6 per game) on 96 receptions (6.0 per game), while being targeted 122 times. He has seven receiving touchdowns.
• Brock Purdy has 2,040 passing yards, 20 touchdowns and nine interceptions. His completion percentage is 69.3% and he averages 255.0 yards per game and 7.9 per attempt.
• Purdy also has three rushing touchdowns and 126 rushing yards (third on the 49ers).
• Mac Jones has thrown for 2,151 yards this year, 13 touchdowns and six interceptions. He is completing 69.6% of his attempts while averaging 195.5 yards per game and 7.4 per attempt.
• Jauan Jennings has 51 catches for 608 yards and nine receiving touchdowns (seventh in the NFL). He averages 3.6 yards per game through 14 games and has been targeted 84 times.

Defense

• Dee Winters' 2025 output includes 99 tackles, 8.0 TFL, and one interception in 16 games. He leads the 49ers in tackles.
• Upton Stout has 76 tackles, 4.0 TFL, and one sack. He is third on the 49ers in tackles.
• Ji'Ayir Brown has intercepted two passes on top of 55 tackles, 2.0 TFL, and six passes defended during the 2025 campaign.
• Tatum Bethune has totaled 3.0 TFL and 84 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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