Patriots vs. Titans 2025 Prediction, Odds, Picks - Oct 19

Updated Oct. 19, 2025 12:43 p.m. ET

Data Skrive

The New England Patriots (4-2) will be aiming to continue a three-game winning streak against the Tennessee Titans (1-5). The Patriots are the favorites, expected to win by at least a field goal but less than a touchdown (currently -6.5). The game has an over/under of 41.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Titans fire head coach Brian Callahan after 1-5 start in first season | The Herd

Albert Breer breaks down what led the Tennessee Titans to firing head coach Brian Callahan after a 1-5 start in his lone season with the team.

Patriots vs. Titans Odds & Betting Lines

Patriots vs Titans Betting Information updated as of October 19, 2025, 12:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Patriots	-6.5	-110	-110	41.5	-108	-112

Patriots vs. Titans Prediction & Pick

Pick ATS: Titans (+6.5)
Pick OU: Over (41.5)
Prediction: Patriots 24 - Titans 19

How to Watch New England vs. Tennessee

Game date: Sunday, October 19, 2025
Time: 1 p.m. ET
Venue: Nissan Stadium
Location: Nashville, Tennessee
TV: CBS
Live Boxscore: FOX Sports

Patriots vs. Titans Recent Matchups

Tennessee holds a 3-2 record against New England in their last five matchups.
Tennessee has been outscored by 10 points in its last five tilts versus New England.

New England Betting Info

New England is 4-2-0 against the spread this year.
New England games this year have hit the over on two of six set point totals (33.3%).
When playing as moneyline favorites, the Patriots are 2-1 (winning 66.7% of the time).
The Patriots have a 74.4% chance to win this contest, based on the implied probability of the moneyline.

Patriots Stats

Stat	Average (Total)	Rank
Pass yards	244.5 (1,467)	6
Rush yards	91.5 (549)	27
Points scored	25.0 (150)	9
Pass yards against	239.0 (1,434)	25
Rush yards against	83.5 (501)	4
Points allowed	20.0 (120)	7

New England's Key Players

Offense

Drake Maye ranks fifth in the NFL with 1,522 passing yards in six games this year, averaging 253.7 per game with a 73.2% completion percentage and 10 touchdowns (10th in the NFL) against two interceptions.
He has tacked on 138 rushing yards (23 per game) and two touchdowns on the ground.
Kayshon Boutte has 18 catches for 301 yards and three TDs. In six games, he is averaging three catches and 50.2 yards per game.
In the passing attack, Hunter Henry, has racked up 277 receiving yards and three touchdowns after hauling in 20 balls on 31 targets. Per game, he's averaging 46.2 yards and 3.3 receptions over six games.
In the running game, Rhamondre Stevenson averages 3.1 yards per attempt (43rd in the NFL) and 26.2 yards per game for 157 total rushing yards. He has recorded two rushing touchdowns this season.
Stevenson has been targeted 15 times and turned those targets into 13 catches, 154 yards and zero TDs.

Defense

On defense for the Patriots, Robert Spillane has racked up 51 tackles, one TFL, one sack, and one interception in 2025.
Harold Landry has 24 tackles, six TFL, and 4.5 sacks this season.
Marcus Jones has totaled one interception and has added 27 tackles, four TFL, one sack, and six passes defended.
So far this season, Jaylinn Hawkins has 22 tackles, two TFL, 1.5 sacks, and one interception.

Tennessee Betting Info

Tennessee has covered the spread twice in six games with a set total.
This year, the Titans have two against the spread wins in three games as an underdog of 6.5 points or more.
This year, Tennessee games have hit the over three times.
This season, the Titans have been the underdog six times and won one of those games.
Bookmakers have implied with the moneyline set for this matchup that the Titans have a 29.9% chance to win.

Titans Stats

Stat	Average (Total)	Rank
Pass yards	150.5 (903)	31
Rush yards	81.8 (491)	31
Points scored	13.8 (83)	31
Pass yards against	209.7 (1,258)	13
Rush yards against	133.7 (802)	25
Points allowed	26.8 (161)	26

Tennessee's Key Players

Offense

Tony Pollard has rushed for two touchdowns this year, and has 362 total rushing yards (60.3 per game and 3.9 per carry).
Pollard has also been a part of the passing attack with 79 yards (13.2 per game) on 11 receptions (1.8 per game), while being targeted 14 times. He is still trying for his first receiving touchdown.
Through six games, Cameron Ward has 1,101 passing yards, with three touchdowns against four interceptions and completing 55% of his passes.
Elic Ayomanor has recorded 196 receiving yards and two touchdowns on 17 receptions, while being targeted 34 times this season.
Calvin Ridley has been targeted 35 times, resulting in 16 catches for 290 yards and zero receiving touchdowns.

Defense

Jeffery Simmons has recorded 4.5 sacks (first on the Titans and eighth in the NFL) to go with eight TFL and 28 tackles through six games in 2025.
Cedric Gray has two TFL and 56 tackles.
Cody Barton has 38 tackles, one TFL, and two interceptions in the 2025 season. He is second on the Titans in tackles.
Amani Hooker's season stats include 30 tackles, two TFL, and one sack through six games. He is third on the Titans in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.