Packers vs. Cardinals 2025 Prediction, Odds, Picks - Oct 19

The Arizona Cardinals (2-4) will be trying to snap a four-game losing run against the Green Bay Packers (3-1-1). The Packers are solid favorites, expected to win by at least a touchdown (currently -7). The game has an over/under of 44.5 points.

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Packers vs. Cardinals Odds & Betting Lines

Packers vs. Cardinals Prediction & Pick

• Pick ATS: Cardinals (+7)
  
• Pick OU: Over (44.5)
  
• Prediction: Cardinals 23 - Packers 22

How to Watch Green Bay vs. Arizona

• Game date: Sunday, October 19, 2025
• Time: 4:25 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Packers vs. Cardinals Recent Matchups

• Over their last three meetings, Green Bay has tallied two wins against Arizona.
• Arizona has been outscored by 21 points in its last three tilts against Green Bay.

Green Bay Betting Info

• Green Bay has covered the spread two times in 2025.
• The Packers have not covered the spread when favored by 7 points or more this season (in two opportunities).
• Green Bay games this year have eclipsed the over/under two times in five opportunities (40%).
• The Packers have won 60% of the time they have played as the moneyline favorite (3-1-1).
• The implied probability in this matchup, considering the moneyline, gives the Packers a 79.2% chance to win.

Packers Stats

Green Bay's Key Players

Offense

• Josh Jacobs' rushing stat line this season includes 359 yards and six TDs. He is averaging 71.8 yards per game and 3.7 per attempt (37th in the NFL).
• Jacobs has been targeted 19 times in the receiving game and has 15 catches (three per game) for 176 yards (35.2 per game) and zero TDs.
• Jordan Love has thrown for 1,259 yards, nine touchdowns and two interceptions this year. He averages 251.8 yards per game and 8.6 per attempt, while completing 70.1%.
• He has tacked on 88 rushing yards (17.6 per game) without a touchdown on the ground.
• Romeo Doubs has four touchdown catches this season (seventh in the NFL), and has 18 catches for 234 yards on 28 targets, while averaging 3.6 catches and 46.8 yards per game.
• Tucker Kraft averages 3.6 receptions and 53.6 yards per game, and has 268 total receiving yards and 18 catches. He's gotten 22 total targets, and has caught three touchdown passes.

Defense

• On the defensive side, Quay Walker has three TFL and 50 tackles in 2025.
• Edgerrin Cooper has 44 tackles, one TFL, and 0.5 sacks this season.
• This season, Rashan Gary has recorded 4.5 sacks (eighth in the NFL) in addition to his four TFL and 18 tackles.
• This season, Keisean Nixon has 22 tackles and two TFL.

Arizona Betting Info

• Arizona is 3-3-0 against the spread this year.
• The Cardinals have been underdogs by 7 points or more once this season and covered the spread.
• This season, three Arizona games have gone over the point total.
• The Cardinals have been the underdog in three games this season, and they have failed to win any of those contests.
• The moneyline for this contest implies a 25.0% chance of a victory for the Cardinals.

Cardinals Stats

Arizona's Key Players

Offense

• In five games played this year, Kyler Murray has racked up 962 passing yards, with six touchdowns against three interceptions and completing 68.3% of his passes.
• On the ground, Murray has added one rushing touchdown and 173 rushing yards (first on the Cardinals).
• Trey McBride has 347 receiving yards and two touchdowns on 37 receptions (eighth in the NFL), while being targeted 53 times.
• Marvin Harrison Jr. has totaled 338 receiving yards and two touchdowns on 22 receptions, while being targeted 34 times this season.
• Jacoby Brissett has 320 passing yards, two touchdowns and one interception. His completion percentage is 60% and he averages 106.7 yards per game and 7.1 per attempt.

Defense

• Mack Wilson's 2025 showing includes 50 tackles, three TFL, and one interception in six games. He leads the Cardinals in tackles.
• Josh Sweat's stat sheet includes 13 tackles, six TFL, five sacks, and one pass defended.
• Akeem Davis-Gaither has 33 tackles and one TFL in the 2025 season. He is fourth on the Cardinals in tackles.
• Jalen Thompson's season stats include 43 tackles through six games. He is second on the Cardinals in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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