NFL Week 4 Predictions, Betting Odds & TV Schedule

The outings in a Week 4 NFL slate sure to please include the Miami Dolphins squaring off against the Buffalo Bills at Highmark Stadium.

Read through our betting breakdown for the NFL's Week 4.

Week 4 Betting Lines & Game Info

Green Bay Packers vs. Detroit Lions

Odds & Prediction

• Spread: Lions (-2)
• Moneyline: Lions -138, Packers +117
• Total: 45 points
• Prediction: Packers 24, Lions 23

How to Watch

• Game Date: Thursday, September 28
• Game Time: 8:15 PM ET
• TV Channel: Amazon Prime Video
• Location: Green Bay, Wisconsin

Jacksonville Jaguars vs. Atlanta Falcons

Odds & Prediction

• Spread: Jaguars (-3)
• Moneyline: Jaguars -175, Falcons +146
• Total: 42.5 points
• Prediction: Jaguars 22, Falcons 18

How to Watch

• Game Date: Sunday, October 1
• Game Time: 9:30 AM ET
• TV Channel: ESPN+
• Location: London, United Kingdom

Tennessee Titans vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-2.5)
• Moneyline: Bengals -148, Titans +124
• Total: 41.5 points
• Prediction: Bengals 21, Titans 17

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Nashville, Tennessee

Chicago Bears vs. Denver Broncos

Odds & Prediction

• Spread: Broncos (-3)
• Moneyline: Broncos -160, Bears +136
• Total: 47 points
• Prediction: Bears 29, Broncos 28

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Chicago, Illinois

Carolina Panthers vs. Minnesota Vikings

Odds & Prediction

• Spread: Vikings (-4.5)
• Moneyline: Vikings -216, Panthers +178
• Total: 46 points
• Prediction: Panthers 24, Vikings 23

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Charlotte, North Carolina

Cleveland Browns vs. Baltimore Ravens

Odds & Prediction

• Spread: Ravens (-2)
• Moneyline: Ravens -133, Browns +112
• Total: 38.5 points
• Prediction: Browns 20, Ravens 19

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Cleveland, Ohio

Indianapolis Colts vs. Los Angeles Rams

Odds & Prediction

• Spread: Rams (-1)
• Moneyline: Rams -115, Colts -105
• Total: 44.5 points
• Prediction: Colts 24, Rams 22

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Indianapolis, Indiana

Buffalo Bills vs. Miami Dolphins

Odds & Prediction

• Spread: Bills (-2.5)
• Moneyline: Bills -144, Dolphins +121
• Total: 53 points
• Prediction: Bills 30, Dolphins 24

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Orchard Park, New York

Houston Texans vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Steelers (-3)
• Moneyline: Steelers -156, Texans +132
• Total: 41.5 points
• Prediction: Texans 23, Steelers 22

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Houston, Texas

New Orleans Saints vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Saints (-4)
• Moneyline: Saints -198, Buccaneers +165
• Total: 41 points
• Prediction: Saints 20, Buccaneers 17

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: New Orleans, Louisiana

Philadelphia Eagles vs. Washington Commanders

Odds & Prediction

• Spread: Eagles (-8.5)
• Moneyline: Eagles -455, Commanders +348
• Total: 43 points
• Prediction: Eagles 28, Commanders 20

How to Watch

• Game Date: Sunday, October 1
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Philadelphia, Pennsylvania

Los Angeles Chargers vs. Las Vegas Raiders

Odds & Prediction

• Spread: Chargers (-6.5)
• Moneyline: Chargers -306, Raiders +243
• Total: 49 points
• Prediction: Chargers 27, Raiders 22

How to Watch

• Game Date: Sunday, October 1
• Game Time: 4:05 PM ET
• TV Channel: CBS
• Location: Inglewood, California

San Francisco 49ers vs. Arizona Cardinals

Odds & Prediction

• Spread: 49ers (-14.5)
• Moneyline: 49ers -1066, Cardinals +675
• Total: 44 points
• Prediction: 49ers 28, Cardinals 17

How to Watch

• Game Date: Sunday, October 1
• Game Time: 4:25 PM ET
• TV Channel: Watch Online: FOX
• Location: Santa Clara, California

Dallas Cowboys vs. New England Patriots

Odds & Prediction

• Spread: Cowboys (-6)
• Moneyline: Cowboys -267, Patriots +216
• Total: 43 points
• Prediction: Cowboys 24, Patriots 15

How to Watch

• Game Date: Sunday, October 1
• Game Time: 4:25 PM ET
• TV Channel: Watch Online: FOX
• Location: Arlington, Texas

New York Jets vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-8)
• Moneyline: Chiefs -437, Jets +337
• Total: 41.5 points
• Prediction: Jets 19, Chiefs 18

How to Watch

• Game Date: Sunday, October 1
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: East Rutherford, New Jersey

New York Giants vs. Seattle Seahawks

Odds & Prediction

• Spread: Seahawks (-2.5)
• Moneyline: Seahawks -141, Giants +119
• Total: 46 points
• Prediction: Giants 29, Seahawks 24

How to Watch

• Game Date: Monday, October 2
• Game Time: 8:15 PM ET
• TV Channel: ABC/ESPN
• Location: East Rutherford, New Jersey