NFL Week 3 Predictions, Betting Odds & TV Schedule

The NFL lineup in Week 3, which includes the New York Giants squaring off against the San Francisco 49ers, should provide some fireworks.

If you're looking for additional betting information for Week 3 in the NFL, we have you covered with betting odds for each of the important matchups.

Week 3 Betting Lines & Game Info

San Francisco 49ers vs. New York Giants

Odds & Prediction

• Spread: 49ers (-10.5)
• Moneyline: 49ers -568, Giants +422
• Total: 43.5 points
• Prediction: 49ers 39, Giants 8

How to Watch

• Game Date: Thursday, September 21
• Game Time: 8:15 PM ET
• TV Channel: Amazon Prime Video
• Location: Santa Clara, California

Washington Commanders vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-5.5)
• Moneyline: Bills -250, Commanders +206
• Total: 44 points
• Prediction: Bills 27, Commanders 21

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Landover, Maryland

Cleveland Browns vs. Tennessee Titans

Odds & Prediction

• Spread: Browns (-3.5)
• Moneyline: Browns -179, Titans +152
• Total: 38 points
• Prediction: Browns 20, Titans 19

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Cleveland, Ohio

Jacksonville Jaguars vs. Houston Texans

Odds & Prediction

• Spread: Jaguars (-7.5)
• Moneyline: Jaguars -374, Texans +299
• Total: 43.5 points
• Prediction: Jaguars 26, Texans 14

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Jacksonville, Florida

Baltimore Ravens vs. Indianapolis Colts

Odds & Prediction

• Spread: Ravens (-7.5)
• Moneyline: Ravens -368, Colts +295
• Total: 43.5 points
• Prediction: Ravens 27, Colts 20

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Baltimore, Maryland

Minnesota Vikings vs. Los Angeles Chargers

Odds & Prediction

• Spread: Vikings (-1)
• Moneyline: Vikings -111, Chargers -108
• Total: 53.5 points
• Prediction: Vikings 28, Chargers 27

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Minneapolis, Minnesota

New York Jets vs. New England Patriots

Odds & Prediction

• Spread: Patriots (-2.5)
• Moneyline: Patriots -142, Jets +121
• Total: 35.5 points
• Prediction: Jets 25, Patriots 16

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: East Rutherford, New Jersey

Green Bay Packers vs. New Orleans Saints

Odds & Prediction

• Spread: Saints (-1)
• Moneyline: Saints -122, Packers +103
• Total: 41.5 points
• Prediction: Packers 24, Saints 20

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Green Bay, Wisconsin

Detroit Lions vs. Atlanta Falcons

Odds & Prediction

• Spread: Lions (-3)
• Moneyline: Lions -170, Falcons +145
• Total: 47 points
• Prediction: Lions 25, Falcons 24

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Detroit, Michigan

Miami Dolphins vs. Denver Broncos

Odds & Prediction

• Spread: Dolphins (-6)
• Moneyline: Dolphins -263, Broncos +217
• Total: 47.5 points
• Prediction: Dolphins 30, Broncos 23

How to Watch

• Game Date: Sunday, September 24
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Miami Gardens, Florida

Seattle Seahawks vs. Carolina Panthers

Odds & Prediction

• Spread: Seahawks (-4.5)
• Moneyline: Seahawks -217, Panthers +181
• Total: 42.5 points
• Prediction: Seahawks 24, Panthers 21

How to Watch

• Game Date: Sunday, September 24
• Game Time: 4:05 PM ET
• TV Channel: CBS
• Location: Seattle, Washington

Kansas City Chiefs vs. Chicago Bears

Odds & Prediction

• Spread: Chiefs (-12.5)
• Moneyline: Chiefs -746, Bears +525
• Total: 48 points
• Prediction: Chiefs 26, Bears 16

How to Watch

• Game Date: Sunday, September 24
• Game Time: 4:25 PM ET
• TV Channel: Watch Online: FOX
• Location: Kansas City, Missouri

Arizona Cardinals vs. Dallas Cowboys

Odds & Prediction

• Spread: Cowboys (-11)
• Moneyline: Cowboys -655, Cardinals +479
• Total: 43.5 points
• Prediction: Cowboys 28, Cardinals 16

How to Watch

• Game Date: Sunday, September 24
• Game Time: 4:25 PM ET
• TV Channel: Watch Online: FOX
• Location: Glendale, Arizona

Las Vegas Raiders vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Raiders (-3)
• Moneyline: Raiders -155, Steelers +132
• Total: 43.5 points
• Prediction: Steelers 22, Raiders 20

How to Watch

• Game Date: Sunday, September 24
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: Paradise, Nevada

Tampa Bay Buccaneers vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-5.5)
• Moneyline: Eagles -253, Buccaneers +208
• Total: 44 points
• Prediction: Eagles 25, Buccaneers 22

How to Watch

• Game Date: Monday, September 25
• Game Time: 7:15 PM ET
• TV Channel: ABC
• Location: Tampa, Florida

Cincinnati Bengals vs. Los Angeles Rams

Odds & Prediction

• Spread: Bengals (-3)
• Moneyline: Bengals -169, Rams +144
• Total: 45.5 points
• Prediction: Rams 22, Bengals 21

How to Watch

• Game Date: Monday, September 25
• Game Time: 8:15 PM ET
• TV Channel: ESPN
• Location: Cincinnati, Ohio