Eagles vs. Broncos 2025 Prediction, Odds, Picks - Oct 5

The Philadelphia Eagles (4-0) will be attempting to continue a four-game winning run against the Denver Broncos (2-2). The Eagles are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The expected point total for the matchup is set at 44.5.

Keep up with the 2025 NFL season on FOX Sports.

Eagles vs. Broncos Odds & Betting Lines

Eagles vs. Broncos Prediction & Pick

• Pick ATS: Eagles (-4.5)
  
• Pick OU: Over (44.5)
  
• Prediction: Eagles 29 - Broncos 16

How to Watch Philadelphia vs. Denver

• Game date: Sunday, October 5, 2025
• Time: 1 p.m. ET
• Venue: Lincoln Financial Field
• Location: Philadelphia, Pennsylvania
• TV: CBS
• Live Boxscore: FOX Sports

Eagles vs. Broncos Recent Matchups

• Over their last two meetings, Philadelphia has totaled two wins against Denver.
• In their last two head-to-head matchups, Philadelphia has tallied 81 points versus Denver, while allowing only 36 points.

Philadelphia Betting Info

• Against the spread, Philadelphia is 3-1-0 this year.
• The Eagles have been favored by 4.5 points or more three times this season, and covered the spread in two of those contests.
• Philadelphia games this year have hit the over on two of four set point totals (50%).
• The Eagles were favored on the moneyline four times this season, and won each of those games.
• The Eagles have an implied win probability, based on the moneyline, of 68.6%.

Eagles Stats

Philadelphia's Key Players

Offense

• Jalen Hurts has passed for 609 yards, five touchdowns and zero interceptions this year. He averages 152.3 yards per game and 6 per attempt, while completing 69.3% of his passes.
• He has also rushed for 179 yards (second on the Eagles) and added four touchdowns on the ground, while averaging 44.8 rushing yards per game.
• Saquon Barkley has put up 237 rushing yards with three touchdowns (59.3 yards per game through four games). His 3.1 yards per attempt rank 40th in the league.
• Barkley's 16 targets in the passing game have turned into 14 catches (3.5 per game) for 70 yards (17.5 per game) and zero touchdowns.
• Dallas Goedert has three touchdown catches this season (eighth in the NFL), and has 12 catches for 114 yards on 13 targets, while averaging four catches and 38 yards per game.
• DeVonta Smith has 17 catches for 158 yards and one touchdown. He's been targeted 20 times in the passing game, and averages 4.3 receptions and 39.5 yards through four games played.

Defense

• On the defensive side, Zack Baun has one sack (second on the Eagles) to go with two TFL, 30 tackles, and one interception in 2025.
• Cooper DeJean has 30 tackles and one TFL this season. He leads the Eagles in tackles.
• This season, Jihaad Campbell has recorded 22 tackles and one interception.
• Quinyon Mitchell has 17 tackles on the year.

Denver Betting Info

• Denver has covered the spread one time this season (1-3-0).
• Denver games have gone over the total once this season.
• The Broncos lost the only game they've played as the underdog this season.
• The implied probability of a win by the Broncos based on the moneyline is 35.7%.

Broncos Stats

Denver's Key Players

Offense

• Bo Nix has thrown for 861 yards this year, with seven touchdowns (eighth in the NFL) and four interceptions. He is completing 65.7% of his passes while averaging 215.3 yards per game and 6.3 per attempt.
• Nix has also rushed for one touchdown and 78 yards (third on the Broncos).
• J.K. Dobbins has scored three rushing touchdowns, while totaling 323 rushing yards (5.7 per attempt and 80.8 per game).
• In four games played this season, Courtland Sutton has 18 catches (4.5 receptions per game on 6.8 targets per game) for 266 yards and three receiving touchdowns (eighth in the NFL).
• Troy Franklin has 18 catches for 196 yards and one receiving touchdown. He averages 4.5 yards per game through four games and has been targeted 27 times.

Defense

• Nik Bonitto has amassed 4.5 sacks (first on the Broncos and third in the NFL) to go with five TFL and 13 tackles over four games in 2025.
• Alex Singleton has 38 tackles and one pass defended.
• During the 2025 season, Brandon Jones has 28 tackles and one interception in four games.
• Talanoa Hufanga's stat sheet includes 28 tackles and two passes defended in four games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Philadelphia Eagles

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