Cowboys vs. Chargers 2025 Prediction, Odds, Picks - Dec 21

The Los Angeles Chargers (10-4) will be attempting to continue a three-game winning streak against the Dallas Cowboys (6-7-1). Despite that, the Cowboys are slim favorites (-1.5). An over/under of 51.5 points has been set for the matchup.

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Cowboys vs. Chargers Odds & Betting Lines

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Cowboys vs. Chargers Prediction & Pick

• Pick ATS: Chargers (+1.5)
  
• Pick OU: Under (51.5)
  
• Prediction: Chargers 26 - Cowboys 25

How to Watch Dallas vs. Los Angeles

• Game date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• Venue: AT&T Stadium
• Location: Arlington, Texas
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Cowboys vs. Chargers Recent Matchups

• Dallas owns a 2-1 record against Los Angeles in their last three matchups.
• Over their last three head-to-head matchups, Los Angeles has racked up 62 points, while Dallas has accumulated 46.

Dallas Betting Info

• Dallas has seven wins in 14 games versus the spread this season.
• The Cowboys have been favored by 1.5 points or more seven times this season, and covered the spread in two of those contests.
• Dallas games this year have hit the over on 10 of 14 set point totals (71.4%).
• When playing as the moneyline favorite, the Cowboys are 3-4 (winning 42.9% of the time).
• The Cowboys have an implied win probability, based on the moneyline, of 55.0%.

Cowboys Stats

Dallas' Key Players

Offense

• Dak Prescott ranks second in the NFL with 3,931 passing yards through 14 games this year, averaging 280.8 per game with a 68.4% completion percentage and 26 touchdowns (third in the NFL) against 10 interceptions.
• He has added 140 rushing yards (10 per game) and two touchdowns on the ground.
• Javonte Williams averages 4.8 yards per carry (11th in the NFL) and 79.5 yards per game, and has 1,113 total rushing yards (sixth in the NFL). He has scored 10 rushing TDs this season.
• Williams' 46 targets as part of the passing attack have turned into 33 catches (2.4 per game) for 128 yards (9.1 per game) and two touchdowns.
• George Pickens has eight touchdown catches this season (seventh in the NFL), and has 81 receptions (eighth in the NFL) for 1,212 yards (third in the NFL) on 120 targets, while averaging 5.8 catches and 86.6 yards per game.
• CeeDee Lamb averages 6.3 receptions and 97.6 yards per game, and has 976 total receiving yards (eighth in the NFL) and 63 catches. He's gotten 99 total targets, and has caught three touchdown passes.

Defense

• On the defensive side, Quinnen Williams has one interception to go with 48 tackles, nine TFL, 2.5 sacks, and one pass defended in 2025.
• Kenneth Murray has 74 tackles, four TFL, and one sack this season. His tackle total leads the Cowboys.
• Osa Odighizuwa has totaled 38 tackles, six TFL, and three sacks this year.
• Shemar James has 56 tackles, two TFL, and one sack.

Los Angeles Betting Info

• Los Angeles has covered the spread eight times this year (8-6-0).
• The Chargers have been underdogs by 1.5 points or more three times this season and are 3-0 ATS in those contests.
• This year, Los Angeles games have hit the over six times.
• This season, the Chargers have been listed as the underdog in three games but won them all.
• The moneyline for this contest implies a 49.5% chance of a victory for the Chargers.

Chargers Stats

Los Angeles' Key Players

Offense

• Justin Herbert has passed for 3,191 yards this year, with 23 touchdowns (seventh in the NFL) and 12 interceptions. He is completing 65.6% of his passes while averaging 227.9 yards per game and 7.1 per attempt.
• Herbert has also rushed for one touchdown and 419 yards (third on the Chargers).
• Ladd McConkey has put together a 2025 stat sheet that includes 61 catches for 715 yards and five receiving touchdowns in 14 games played. He has been on the receiving end of 98 targets and is averaging 4.4 receptions per game.
• Kimani Vidal is averaging 56.4 rushing yards per game this season (620 total yards), while scoring three rushing touchdowns.
• Vidal's stat sheet includes 15 receptions (1.4 per game) on 21 targets for 138 yards (12.5 per game) and one receiving touchdown.
• Quentin Johnston has been targeted 72 times, resulting in 42 catches for 533 yards (ninth in the NFL).

Defense

• So far in 2025, Tuli Tuipulotu has amassed 39 tackles, 19 TFL, and 12 sacks through 13 games.
• Daiyan Henley has registered 3.5 sacks in addition to his five TFL, 84 tackles, and two interceptions over 14 games.
• Derwin James has intercepted two passes on top of 80 tackles, six TFL, two sacks, and six passes defended during the 2025 campaign.
• Odafe Oweh's stats include 31 tackles, nine TFL, and seven sacks in 14 games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Dallas Cowboys

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