Colts vs. Texans 2025 Prediction, Odds, Picks - Nov 30

Having taken three in a row, the Houston Texans (6-5) will face the Indianapolis Colts (8-3). Despite that, the Colts are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3). The expected point total for the matchup is set at 44.5.

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Colts vs. Texans Odds & Betting Lines

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Colts vs. Texans Prediction & Pick

• Pick ATS: Colts (-3)
  
• Pick OU: Over (44.5)
  
• Prediction: Colts 25 - Texans 21

How to Watch Indianapolis vs. Houston

• Game date: Sunday, November 30, 2025
• Time: 1 p.m. ET
• Venue: Lucas Oil Stadium
• Location: Indianapolis, Indiana
• TV: CBS
• Live Boxscore: FOX Sports

Colts vs. Texans Recent Matchups

• Over their last five meetings, Houston has collected four wins against Indianapolis.
• Houston has been outpaced by 1 point in its last five tilts against Indianapolis.

Indianapolis Betting Info

• Indianapolis is 7-4-0 against the spread this year.
• The Colts have covered the spread three times this season (3-3 ATS) when playing as at least 3-point favorites.
• Indianapolis games this year have gone over the total in six out of 11 opportunities (54.5%).
• When playing as moneyline favorites, the Colts are 6-1, earning a victory 85.7% of the time.
• The Colts have an implied win probability, based on the moneyline, of 63.0%.

Colts Stats

Indianapolis' Key Players

Offense

• On the ground, Jonathan Taylor averages 5.8 yards per attempt (first in the NFL) and 108.8 yards per game for 1,197 total rushing yards (first in the NFL). He has recorded 15 rushing touchdowns this season.
• Taylor has 35 targets, 32 catches, 268 receiving yards and two TDs in the passing game.
• Daniel Jones has 2,840 passing yards (fifth in the NFL), 17 touchdowns and seven interceptions this year. He has completed 69.1% of his attempts, averaging 258.2 yards per game and 8.1 per attempt.
• He has tacked on 159 rushing yards (14.5 per game) and five touchdowns on the ground.
• Michael Pittman Jr. has seven touchdown catches this season (fourth in the NFL), and has 59 receptions for 607 yards on 78 targets, while averaging 5.4 catches and 55.2 yards per game.
• Tyler Warren averages 5.0 receptions and 60.2 yards per game, and has 662 total receiving yards and 55 catches. He's gotten 74 total targets, and has caught three touchdown passes.

Defense

• On the defensive side for the Colts, Nick Cross has racked up 77 tackles, 4.0 TFL, 2.5 sacks, and one interception in 2025.
• Zaire Franklin has 74 tackles, 4.0 TFL, and two sacks this season.
• This season, Germaine Pratt has put up 5.0 TFL and 83 tackles.
• So far this season, Laiatu Latu has 32 tackles, 6.0 TFL, six sacks, and three interceptions.

Houston Betting Info

• Houston has covered the spread five times this season (5-6-0).
• The Texans have covered the spread once this year when underdogs by 3 points or more (in three chances).
• This year, Houston games have hit the over three times.
• This season, the Texans have won two out of the five games in which they've been the underdog.
• The moneyline for this contest implies a 41.3% chance of a victory for the Texans.

Texans Stats

Houston's Key Players

Offense

• C.J. Stroud has passed for 1,702 yards this year, with 11 touchdowns and five interceptions. He is completing 66.5% of his passes while averaging 212.8 yards per game and 7.0 per attempt.
• On the ground, Stroud has added 189 rushing yards (third on the Texans).
• Nico Collins has 52 catches for 697 yards and four receiving touchdowns. He has been targeted 85 times and averages 5.2 receptions per game through 10 games played.
• This season through 11 games, Woody Marks has racked up 422 rushing yards (second on the Texans) and scored two rushing touchdowns. He averages 38.4 yards per game and 3.7 per attempt (38th in the NFL).
• Marks has helped in the passing game, picking up 185 receiving yards (16.8 per game) on 17 catches (1.5 per game), while being targeted 26 times. He has two receiving touchdowns.
• Through five games, Davis Mills has 879 passing yards, while throwing five touchdowns against one interception and completing 58.7% of his passes.
• Mills also has one rushing touchdown and 48 rushing yards (fourth on the Texans).

Defense

• Will Anderson Jr. has 10.5 sacks (second on the Texans and fifth in the NFL) to go with 14.0 TFL and 36 tackles over 11 games in 2025.
• Danielle Hunter has 11.0 sacks in addition to his 11.0 TFL and 37 tackles over 10 games. He's fourth in the NFL in sacks.
• In the 2025 season, Kamari Lassiter has 63 tackles, 6.0 TFL, and two interceptions in 11 games.
• Azeez Al-Shaair has 72 tackles, 1.0 TFL, and seven passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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