Chiefs vs. Broncos 2025 Prediction, Odds, Picks - Nov 16

The Kansas City Chiefs (5-4) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5) over the Denver Broncos (8-2), despite the Broncos having taken seven games straight. The total for this one is set at 45.5 points.

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Chiefs vs. Broncos Odds & Betting Lines

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Chiefs vs. Broncos Prediction & Pick

• Pick ATS: Broncos (+4.5)
  
• Pick OU: Under (45.5)
  
• Prediction: Broncos 23 - Chiefs 20

How to Watch Kansas City vs. Denver

• Game date: Sunday, November 16, 2025
• Time: 4:25 p.m. ET
• Venue: Empower Field at Mile High
• Location: Denver, Colorado
• TV: CBS
• Live Boxscore: FOX Sports

Chiefs vs. Broncos Recent Matchups

• Over their last five meetings, Kansas City has collected three wins versus Denver.
• Over their last five head-to-head matchups, Denver has racked up 108 points, while Kansas City has tallied 71.

Kansas City Betting Info

• Against the spread, Kansas City is 5-4-0 this season.
• The Chiefs have been favored by 4.5 points or more three times this season, and covered the spread in each of them.
• Kansas City games this year have hit the over on three of nine set point totals (33.3%).
• When playing as moneyline favorites, the Chiefs are 4-3, winning 57.1% of the time.
• Looking at this contest's moneyline, the Chiefs' implied win probability is 69.7%.

Chiefs Stats

Kansas City's Key Players

Offense

• Patrick Mahomes has 2,349 passing yards (fifth in the NFL), 17 touchdowns (seventh in the NFL) and five interceptions this year. He has completed 64.6% of his attempts, averaging 261 yards per game and 7.4 per attempt.
• He has tacked on 285 rushing yards (31.7 per game) and four touchdowns on the ground.
• Travis Kelce has caught 41 passes on 53 targets for 540 total yards and three touchdowns. He is averaging 4.6 catches and 60 yards per game through nine games.
• Kareem Hunt's output on the ground this season includes 294 yards and five TDs. He's averaging 32.7 yards per game and 4 per attempt (30th in the NFL).
• Hunt has been on the receiving end of 11 targets in the passing game and has nine catches (one per game) for 63 yards (7 per game) and one TD.
• Marquise Brown has 34 catches for 389 yards and four touchdowns. He's been targeted 53 times in the air attack, and averages 3.8 receptions and 43.2 yards in nine games played.

Defense

• Over on defense, Nick Bolton has 75 tackles and five TFL in 2025.
• George Karlaftis III has five sacks (first on the Chiefs) to go with seven TFL and 32 tackles.
• This season, Chamarri Conner has recorded 62 tackles.
• Trent McDuffie has one sack in addition to his one TFL, 47 tackles, and one interception on the season.

Denver Betting Info

• Denver has covered the spread four times over 10 games with a set total.
• This year, the Broncos won ATS in their only game as an underdog of 4.5 points or more.
• Games involving Denver have hit the over on three occasions this year.
• This season, the Broncos have won two out of the three games in which they've been the underdog.
• The Broncos have a 34.5% chance to win this game based on the implied probability of the moneyline.

Broncos Stats

Denver's Key Players

Offense

• Bo Nix has passed for 2,126 yards this year, with 18 touchdowns (fifth in the NFL) and eight interceptions. He is completing 60.9% of his passes while averaging 212.6 yards per game and 6.1 per attempt.
• Nix has also rushed for three touchdowns and 205 yards (third on the Broncos).
• Courtland Sutton has put together a 2025 stat sheet that includes 41 catches for 590 yards and four receiving touchdowns over 10 games played. He has been on the receiving end of 66 targets and is averaging 4.1 receptions per game.
• Troy Franklin has put up 425 receiving yards and five touchdowns on 42 receptions, while being targeted 73 times on the season.
• RJ Harvey has 214 rushing yards (second on the Broncos) and two rushing touchdowns, while averaging 21.4 yards per game and 4.3 per attempt.
• Harvey has also added 25 catches (2.5 per game) for 175 yards (17.5 per game) and four receiving touchdowns. He has been on the receiving end of 29 targets.

Defense

• In 2025, Nik Bonitto has recorded 9.5 sacks to go with nine TFL and 32 tackles over 10 games. He ranks third in the NFL in sacks.
• Talanoa Hufanga has registered two sacks in addition to his three TFL and 70 tackles over 10 games.
• Alex Singleton has 89 tackles, three TFL, and one sack in the 2025 season. He leads the Broncos and is fifth in the NFL in tackles.
• Zach Allen's stat sheet includes 28 tackles, three TFL, six sacks, and six passes defended in 10 games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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