Broncos vs. Jaguars 2025 Prediction, Odds, Picks - Dec 21

In a matchup featuring two teams coming off wins, the Denver Broncos (12-2) will play the Jacksonville Jaguars (10-4). The Broncos have taken 11 in a row, the Jaguars five in a row. Denver is favored by 3.5 points. The game has an over/under of 46.5 points.

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Broncos vs. Jaguars Odds & Betting Lines

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Broncos vs. Jaguars Prediction & Pick

• Pick ATS: Jaguars (+3.5)
  
• Pick OU: Under (46.5)
  
• Prediction: Jaguars 23 - Broncos 22

How to Watch Denver vs. Jacksonville

• Game date: Sunday, December 21, 2025
• Time: 4:05 p.m. ET
• Venue: Empower Field at Mile High
• Location: Denver, Colorado
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Broncos vs. Jaguars Recent Matchups

• Over their last three meetings, Denver has put up two wins versus Jacksonville.
• Over their last three head-to-head contests, Denver has scored 68 points, while Jacksonville has compiled 56.

Denver Betting Info

• In 14 Denver games this year, it has six wins against the spread.
• The Broncos have covered the spread twice this season (2-6 ATS) when playing as at least 3.5-point favorites.
• Denver has combined with its opponent to eclipse the over/under in 42.9% of its contests this year (six times in 14 games with a set point total).
• The Broncos have put together an 8-1 record in games they played as moneyline favorite (winning 88.9% of those games).
• Based on this game's moneyline, the Broncos' implied win probability is 63.6%.

Broncos Stats

Denver's Key Players

Offense

• Bo Nix has thrown for 3,256 yards (10th in the NFL), 23 touchdowns (seventh in the NFL) and nine interceptions this year. He is averaging 232.6 yards per game and 6.5 per attempt, while completing 63.5% of his passes.
• He has also rushed for 254 yards (third on the Broncos) and added four touchdowns on the ground, while averaging 18.1 rushing yards per game.
• Courtland Sutton has 63 catches for 886 yards and six TDs. In 14 games, he is averaging 4.5 catches and 63.3 yards per game.
• RJ Harvey's output on the ground this season includes 419 yards and six TDs. He's averaging 29.9 yards per game and 3.8 per attempt (40th in the NFL).
• Harvey has 37 receptions on 43 targets for 247 yards, with four receiving TDs.
• Troy Franklin has 626 receiving yards and six touchdowns with 57 catches on 94 targets. He's averaging 4.1 receptions and 44.7 yards per game.

Defense

• On defense, Nik Bonitto has 41 tackles, 13.0 TFL, and 12.5 sacks in 2025.
• Talanoa Hufanga has 2.0 sacks in addition to his 6.0 TFL and 97 tackles.
• Alex Singleton has recorded 111 tackles, 3.0 TFL, and one sack this year. He leads the Broncos in tackles.
• Zach Allen has 33 tackles, 3.0 TFL, 6.5 sacks, and six passes defended.

Jacksonville Betting Info

• Jacksonville has covered the spread nine times this year (9-5-0).
• The Jaguars have been underdogs by 3.5 points or more three times this season and have covered the spread twice.
• Jacksonville games have gone over the total eight times this season.
• The Jaguars have been underdogs in seven games this season and won four (57.1%) of those contests.
• The Jaguars have a 40.8% chance to win this game based on the implied probability of the moneyline.

Jaguars Stats

Jacksonville's Key Players

Offense

• In 14 games played this year, Trevor Lawrence has totaled 3,210 passing yards, while throwing 23 touchdowns (seventh in the NFL) against 11 interceptions and completing 59.7% of his passes.
• He's added 302 yards on the ground (second on the Jaguars), while scoring six rushing touchdowns. He's averaging 21.6 yards per game and 4.6 per attempt.
• Travis Etienne has 949 rushing yards (leading the Jaguars) and seven rushing touchdowns, while averaging 67.8 yards per game and 4.5 per attempt (21st in the NFL).
• Etienne has also collected 254 receiving yards (18.1 per game) on 29 catches (2.1 per game). He's been targeted 43 times and has caught five touchdown passes.
• So far this season, Jakobi Meyers has caught 60 passes for 707 receiving yards with three touchdowns in the passing game. He has been targeted 87 total times and is averaging 4.6 receptions per game through 13 games played.
• Parker Washington has 39 catches for 500 yards and three receiving touchdowns. He averages 3.0 yards per game in 13 games and has been targeted 66 times.

Defense

• Foyesade Oluokun has 1.0 sack to go with 5.0 TFL, 111 tackles, and one interception over 14 games in 2025.
• Devin Lloyd has 1.5 sacks to go with 5.0 TFL, 59 tackles, and five interceptions.
• Josh Hines-Allen has 40 tackles, 11.0 TFL, and seven sacks in the 2025 campaign.
• Andrew Wingard has intercepted one pass and also has 78 tackles, 2.0 TFL, and eight passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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