Bills vs. Dolphins 2025 Prediction, Odds, Picks - Sep 18

The Buffalo Bills (2-0) are heavy favorites (-12.5) versus the Miami Dolphins (0-2) in a matchup of two division rivals. The expected point total for the matchup is set at 50.5.

Keep up with the 2025 NFL season on FOX Sports.

Mahomes Mountain Week 3: Will Mahomes be dethroned? | First Things First

Nick Wright lists his QB hierarchy entering Week 3 of the 2025/26 NFL season, including Mac Jones, Tua Tagovailoa, Jalen Hurts, Patrick Mahomes, and Josh Allen.

Bills vs. Dolphins Odds & Betting Lines

Bills vs. Dolphins Prediction & Pick

• Pick ATS: Bills (-12.5)
  
• Pick OU: Under (50.5)
  
• Prediction: Bills 32 - Dolphins 15

How to Watch Buffalo vs. Miami

• Game date: Thursday, September 18, 2025
• Time: 8:15 p.m. ET
• Venue: Highmark Stadium
• Location: Orchard Park, New York
• TV: Amazon Prime Video
• Live Boxscore: FOX Sports

Bills vs. Dolphins Recent Matchups

• Over their last five meetings, Buffalo has collected five wins versus Miami.
• Over their last five head-to-head matchups, Buffalo has racked up 164 points, while Miami has accumulated 102.

Buffalo Betting Info

• So far this season Buffalo has two victories against the spread.
• Buffalo games this year have hit the over on one of two set point totals (50%).
• The Bills have been moneyline favorites one other time this season, a game they won.
• The Bills have an implied win probability, based on the moneyline, of 89.4%.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 542 passing yards (seventh in the NFL), two touchdowns and zero interceptions this year. He has completed 66.2% of his attempts, averaging 271 yards per game and 7.6 per attempt.
• He has also rushed for 89 yards (second on the Bills) and added two touchdowns on the ground, while averaging 44.5 rushing yards per game.
• James Cook's rushing output this season includes 176 yards (fourth in the NFL) and three TDs. He's averaging 88 yards per game and 5.2 per attempt (ninth in the NFL).
• He has also caught six passes (on six targets) for 61 receiving yards with zero touchdowns. He's averaging 30.5 receiving yards and three catches per game.
• Keon Coleman has one touchdown catch this season, and has 11 catches for 138 yards on 14 targets, while averaging 5.5 catches and 69 yards per game.
• Dalton Kincaid has eight catches for 85 yards and one touchdown. He's been targeted 10 times in the passing game, and averages four receptions and 42.5 yards in two games played.

Defense

• On the defensive side, Joey Bosa has four tackles, one TFL, and one sack in 2025.
• Ed Oliver has six tackles, three TFL, and one sack this season.
• Cole Bishop has recorded nine tackles, one TFL, and one sack this year.
• This season, Matt Milano has nine tackles, one TFL, and one sack.

Miami Betting Info

• Miami is winless against the spread this year (0-2-0).
• This year, Miami games have hit the over just once.
• The Dolphins lost the only game they've played as the underdog this season.
• The Dolphins have a 14.8% chance to win this game based on the implied probability of the moneyline.

Dolphins Stats

Miami's Key Players

Offense

• So far this year in two games, De'Von Achane has racked up 85 rushing yards (leading the Dolphins), but has not scored a rushing touchdown. He averages 42.5 yards per game and 4.7 per attempt (12th in the NFL).
• Achane has also been a piece of the passing attack with 112 yards (56 per game) on 11 receptions (5.5 per game), while being targeted 14 times. He has two receiving touchdowns.
• Tua Tagovailoa has 429 passing yards, three touchdowns (10th in the NFL) and three interceptions. His completion percentage is 72.7% and he averages 214.5 yards per game and 7.8 per attempt.
• So far this season, Jaylen Waddle has caught nine passes for 98 receiving yards with one touchdown through the air. He has been targeted 11 total times and is averaging 4.5 receptions per game through two games played.
• Tyreek Hill has 149 receiving yards from 10 receptions after getting 13 targets.

Defense

• In 2025, Jordyn Brooks has 22 tackles, two TFL, and one sack over two games.
• Tyrel Dodson has totaled one TFL and 22 tackles through two games.
• Minkah Fitzpatrick has 15 tackles.
• Bradley Chubb has totaled two sacks (first on the Dolphins and eighth in the NFL) as well as two TFL and six tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Buffalo Bills

Miami Dolphins