Bills vs. Browns 2025 Prediction, Odds, Picks - Dec 21

The Buffalo Bills (10-4) are heavy favorites (-10.5) over the Cleveland Browns (3-11). The Browns have lost three games straight. The game has an over/under of 41.5 points.

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Bills vs. Browns Odds & Betting Lines

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Bills vs. Browns Prediction & Pick

• Pick ATS: Bills (-10.5)
  
• Pick OU: Over (41.5)
  
• Prediction: Bills 31 - Browns 15

How to Watch Buffalo vs. Cleveland

• Game date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• Venue: Huntington Bank Field
• Location: Cleveland, Ohio
• TV: CBS
• Live Boxscore: FOX Sports

Bills vs. Browns Recent Matchups

• In their past two matchups, Cleveland holds a split 1-1 record against Buffalo.
• In their last two head-to-head matchups, Buffalo has tallied 47 points versus Cleveland, while allowing only 42 points.

Buffalo Betting Info

• In 14 Buffalo games this season, it has seven wins against the spread.
• The Bills have not covered the spread this season (0-2 ATS) when playing as at least 10.5-point favorites.
• Buffalo contests this year have gone over the point total 50% of the time (seven times in 14 games with a set point total).
• The Bills have an 8-4 record in games they played as the moneyline favorite (winning 66.7% of those games).
• The Bills have an 87.1% chance to win this game, based on the implied probability of the moneyline.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has passed for 3,276 yards (eighth in the NFL), 25 touchdowns (fourth in the NFL) and 10 interceptions this year. He averages 234 yards per game and 8.1 per attempt, while completing 70% of his attempts.
• In addition to his passing statistics, Allen also has 535 rushing yards (second on the Bills), with 12 rushing touchdowns.
• James Cook's rushing statline this season includes 1,415 yards (second in the NFL) and 10 TDs. He's averaging 101.1 yards per game and 5.2 per attempt (seventh in the NFL).
• He's also caught 31 passes (on 34 targets) for 271 receiving yards with two touchdowns. He's averaging 19.4 receiving yards and 2.2 catches per game.
• In 14 games played, Khalil Shakir is averaging 46.4 yards and 4.4 receptions per game to total 650 receiving yards and 62 catches. He's been targeted 83 times, and has four receiving touchdowns.
• Dalton Kincaid averages 3.6 receptions and 52.3 yards per game, and has 523 total receiving yards and 36 catches. He's gotten 45 total targets, and has caught five touchdown passes.

Defense

• Over on the defensive side, Cole Bishop has 76 tackles, three TFL, two sacks, and three interceptions in 2025. His tackle total leads the Bills.
• Joey Bosa has 26 tackles, eight TFL, and five sacks this season.
• Terrel Bernard has put up 56 tackles, seven TFL, and one interception this year. He's second on the Bills in tackles.
• Greg Rousseau has four sacks (second on the Bills) to go with his four TFL and 40 tackles this year.

Cleveland Betting Info

• Cleveland has covered the spread five times over 14 games with a set total.
• The Browns have been underdogs by 10.5 points or more one time this season and have not covered the spread once.
• Games involving Cleveland have hit the over on seven occasions this year.
• This season, the Browns have won two out of the 11 games, or 18.2%, in which they've been the underdog.
• The Browns have a 16.9% chance to win this game based on the implied probability of the moneyline.

Browns Stats

Cleveland's Key Players

Offense

• So far this year through 13 games, Quinshon Judkins has churned out 805 rushing yards (leading the Browns) and scored seven rushing touchdowns. He averages 61.9 yards per game and 3.6 per attempt (42nd in the NFL).
• On top of his rushing statistics, Judkins has caught 21 passes (on 30 targets) for 142 yards (seventh on the Browns). He's averaging 10.9 yards per game.
• Harold Fannin has put together a 2025 stat sheet that includes 66 catches for 667 yards and four receiving touchdowns over 14 games played. He has been on the receiving end of 99 targets and is averaging 4.7 receptions per game.
• Dillon Gabriel has passed for 937 yards this year, seven touchdowns and two interceptions. He is completing 59.5% of his attempts while averaging 104.1 yards per game and 5.1 per attempt.
• Jerry Jeudy has 519 receiving yards and two touchdowns from 40 receptions after receiving 89 targets.

Defense

• Myles Garrett's 2025 showing includes 57 tackles, 32 TFL, and 21.5 sacks in 14 games.
• Carson Schwesinger has 1.5 sacks to go with 10 TFL, 124 tackles, and two interceptions.
• During the 2025 campaign, Devin Bush Jr. has 92 tackles, six TFL, two sacks, and two interceptions through 14 games.
• Tyson Campbell has intercepted one pass to go with 77 tackles, one TFL, and 16 passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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