Bills vs. Bengals 2025 Prediction, Odds, Picks - Dec 7

The Buffalo Bills (8-4) are considered favorites (-6.5) according to the point spread ahead of their game against the Cincinnati Bengals (4-8) on December 7, 2025, starting at 1 p.m. ET, airing on FOX. The over/under for this one is set at 54.5 points.

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Bills vs. Bengals Odds & Betting Lines

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Bills vs. Bengals Prediction & Pick

• Pick ATS: Bills (-6.5)
  
• Pick OU: Under (54.5)
  
• Prediction: Bills 34 - Bengals 18

How to Watch Buffalo vs. Cincinnati

• Game date: Sunday, December 7, 2025
• Time: 1 p.m. ET
• Venue: Highmark Stadium
• Location: Orchard Park, New York
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Bills vs. Bengals Recent Matchups

• In their last four head-to-head meetings, Cincinnati has beaten Buffalo three times.
• Over their last four head-to-head contests, Cincinnati has scored 88 points, while Buffalo has accumulated 65.

Buffalo Betting Info

• Buffalo has played 12 games, posting six wins against the spread.
• The Bills have covered the spread three times this season (3-4 ATS) when playing as at least 6.5-point favorites.
• Buffalo has combined with its opponent to gone over the point total in 41.7% of its contests this year (five times over 12 games with a set point total).
• When playing as the moneyline favorite, the Bills have won 60% of the time (6-4).
• The Bills have a 74.0% chance to win this game, based on the implied probability of the moneyline.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 2,832 passing yards (ninth in the NFL), 19 touchdowns (seventh in the NFL) and 10 interceptions this year. He has completed 69.4% of his attempts, averaging 236.0 yards per game and 8.1 per attempt.
• In addition to his passing statistics, Allen has 409 rushing yards (second on the Bills), with 11 rushing touchdowns.
• James Cook's rushing statline this season includes 1,228 yards (second in the NFL) and eight TDs. He is averaging 102.3 yards per game and 5.3 per attempt (fourth in the NFL).
• Cook has 27 receptions on 29 targets for 236 yards. He has one receiving TD.
• In 12 games played, Khalil Shakir is averaging 47.4 yards and 4.6 receptions per game to total 569 receiving yards and 55 catches. He's been targeted 75 times, and has three receiving touchdowns.
• Dalton Kincaid has 448 receiving yards and four touchdowns with 29 catches on 36 targets. He is averaging 3.6 receptions and 56.0 yards per game.

Defense

• On the defensive side, Cole Bishop has 65 tackles, 3.0 TFL, two sacks, and three interceptions in 2025. His tackle total leads the Bills.
• Joey Bosa has 26 tackles, 8.0 TFL, and five sacks this season.
• Terrel Bernard has collected 56 tackles, 7.0 TFL, and one interception this year.
• Greg Rousseau has 3.0 sacks (second on the Bills) in addition to his 4.0 TFL and 36 tackles this year.

Cincinnati Betting Info

• Cincinnati has gone 5-7-0 against the spread this season.
• The Bengals are 3-2 ATS when underdogs by 6.5 points or more this season.
• This season, Cincinnati games have hit the over seven times.
• The Bengals have been underdogs in nine games this season and won two (22.2%) of those contests.
• The moneyline for this contest implies a 30.3% chance of a victory for the Bengals.

Bengals Stats

Cincinnati's Key Players

Offense

• In 10 games played this year, Joe Flacco has amassed 2,451 passing yards, while throwing 15 touchdowns against 10 interceptions and completing 60.2% of his attempts.
• On the ground, Flacco has added one rushing touchdown and 31 rushing yards (fourth on the Bengals).
• Ja'Marr Chase has 971 receiving yards (fifth in the NFL) and five touchdowns on 86 receptions (second in the NFL), while being targeted 131 times.
• So far this season in 12 games, Chase Brown has racked up 704 rushing yards (leading the Bengals) and scored two rushing touchdowns. He averages 58.7 yards per game and 4.4 per attempt (23rd in the NFL).
• Brown's offensive output includes 48 receptions (4.0 per game) on 64 targets for 287 yards (23.9 per game) and one receiving touchdown.
• Tee Higgins has been targeted 70 times, resulting in 40 catches for 575 yards (fifth in the NFL).

Defense

• In 2025, Jordan Battle has put up 1.0 TFL, 86 tackles, and three interceptions over 12 games.
• Geno Stone has 1.0 sack in addition to his 2.0 TFL, 84 tackles, and two interceptions through 12 games.
• Demetrius Knight II has intercepted two passes on top of 83 tackles, 2.0 TFL, and six passes defended in the 2025 season.
• Daxton Hill has totaled 2.0 TFL, 71 tackles, and one interception.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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