Bills vs. Bengals 2025 Prediction, Odds, Picks - Dec 7

The Buffalo Bills (8-4) are favored by 5.5 points versus the Cincinnati Bengals (4-8) on December 7, 2025, starting at 1 p.m. ET, airing on FOX. The expected point total for the matchup is set at 53.5.

Keep up with the 2025 NFL season on FOX Sports.

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On the Week 14 edition of Must-Win, Nick Wright, Chris Broussard, Kevin Wildes, and Greg Jennings discuss which games are a must-win. These include the matchups between the Chicago Bears and Green Bay Packers, Philadelphia Eagles and Los Angeles Chargers, and the Cincinnati Bengals and the Buffalo Bills.

Bills vs. Bengals Odds & Betting Lines

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Bills vs. Bengals Prediction & Pick

• Pick ATS: Bills (-5.5)
  
• Pick OU: Under (53.5)
  
• Prediction: Bills 34 - Bengals 18

How to Watch Buffalo vs. Cincinnati

• Game date: Sunday, December 7, 2025
• Time: 1 p.m. ET
• Venue: Highmark Stadium
• Location: Orchard Park, New York
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Bills vs. Bengals Recent Matchups

• Over their last four meetings, Cincinnati has put up three wins against Buffalo.
• Over their last four head-to-head contests, Cincinnati has put up 88 points, while Buffalo has posted 65.

Buffalo Betting Info

• Buffalo is 6-6-0 against the spread this season.
• The Bills are 3-5 ATS this season when playing as at least 5.5-point favorites.
• Buffalo has combined with its opponent to hit the over in 41.7% of its contests this year (five times over 12 games with a set point total).
• The Bills have won 60% of the time they have played as moneyline favorites (6-4).
• The Bills have an implied win probability, based on the moneyline, of 74.0%.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 2,832 passing yards (ninth in the NFL), 19 touchdowns (seventh in the NFL) and 10 interceptions this year. He has completed 69.4% of his attempts, averaging 236.0 yards per game and 8.1 per attempt.
• In addition to his passing statistics, Allen also has 409 rushing yards (second on the Bills), with 11 rushing touchdowns.
• James Cook averages 5.3 yards per carry (fourth in the NFL) and 102.3 yards per game, and has 1,228 total rushing yards (second in the NFL). He has recorded eight rushing TDs this season.
• Cook's 29 targets as part of the passing attack have resulted in 27 catches (2.3 per game) for 236 yards (19.7 per game) and one touchdown.
• In 12 games played, Khalil Shakir is averaging 47.4 yards and 4.6 receptions per game to total 569 receiving yards and 55 catches. He's been targeted 75 times, and has three receiving touchdowns.
• Dalton Kincaid has racked up 448 receiving yards and four touchdowns with 29 catches on 36 targets. He's averaging 3.6 receptions and 56.0 yards per game.

Defense

• On the defensive side, Cole Bishop has 65 tackles, 3.0 TFL, two sacks, and three interceptions in 2025.
• Joey Bosa has 26 tackles, 8.0 TFL, and five sacks.
• This season, Terrel Bernard has recorded 7.0 TFL, 56 tackles, and one interception.
• Greg Rousseau has 3.0 sacks (second on the Bills) in addition to his 4.0 TFL and 36 tackles this year.

Cincinnati Betting Info

• Cincinnati has covered the spread five times over 12 games with a set total.
• The Bengals have an ATS record of 3-3 in their six games when underdogs by 5.5 points or more this season.
• This season, seven Cincinnati games have gone over the point total.
• This season, the Bengals have been the underdog nine times and won two of those games.
• The bookmakers' moneyline implies a 30.3% chance of a victory for the Bengals.

Bengals Stats

Cincinnati's Key Players

Offense

• Joe Flacco is averaging 6.0 passing yards per attempt (31st in the NFL) and 245.1 yards per game this year, completing 60.2% of his passes on the way to 2,451 total yards, 15 touchdowns and 10 interceptions through 10 games.
• Flacco has also rushed for one touchdown and 31 yards (fourth on the Bengals).
• Ja'Marr Chase has 86 catches (second in the NFL) for 971 yards (fifth in the NFL) and five receiving touchdowns. He has been targeted 131 times and averages 7.8 receptions per game through 11 games played.
• This season through 12 games, Chase Brown has churned out 704 rushing yards (leading the Bengals) and scored two rushing touchdowns. He averages 58.7 yards per game and 4.4 per carry (23rd in the NFL).
• Brown's stat sheet includes 48 receptions (4.0 per game) on 64 targets for 287 yards (23.9 per game) and one receiving touchdown.
• Tee Higgins has been targeted 70 times, resulting in 40 catches for 575 yards (fifth in the NFL).

Defense

• Jordan Battle has amassed 1.0 TFL, 86 tackles, and three interceptions over 12 games in 2025.
• Geno Stone has two interceptions on top of 84 tackles, 2.0 TFL, one sack, and three passes defended.
• Demetrius Knight II has 83 tackles, 2.0 TFL, and two interceptions in the 2025 campaign. He is third on the Bengals in tackles.
• Daxton Hill has totaled 2.0 TFL, 71 tackles, and one interception.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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