49ers vs. Seahawks 2025 Prediction, Odds, Picks - Sep 7

The San Francisco 49ers (0-0) are slight favorites (-1.5) against the Seattle Seahawks (0-0) in a matchup of two division rivals. The expected point total for the matchup is set at 43.5.

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Charissa Thompson broke down what to expect from Titans No. 1 pick Cam Ward in his debut, and previewed the highly anticipated division clash between the 49ers and Seahawks, with both Brock Purdy and Sam Darnold coming off new deals this offseason.

49ers vs. Seahawks Odds & Betting Lines

49ers vs. Seahawks Prediction & Pick

• Pick ATS: Seahawks (+1.5)
  
• Pick OU: Over (43.5)
  
• Prediction: Seahawks 27 - 49ers 19

How to Watch San Francisco vs. Seattle

• Game date: Sunday, September 7, 2025
• Time: 4:05 p.m. ET
• Venue: Lumen Field
• Location: Seattle, Washington
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

49ers vs. Seahawks Recent Matchups

• Over their last five meetings, San Francisco has put up four wins against Seattle.
• In their last five head-to-head matchups, San Francisco has tallied 153 points versus Seattle, while giving up only 96 points.

San Francisco Betting Info

• San Francisco covered five times in 17 matchups with a spread last season.
• Against the spread, as 1.5-point favorites or more, the 49ers went 5-8 last season.
• San Francisco games went over the point total 10 out of 17 times last season.
• The 49ers put together a 6-7 record in games they were favored on the moneyline last season (winning 46.2% of those games).
• San Francisco went 6-6 last year (winning 50% of its games) when playing as a moneyline favorite of -130 or shorter.
• Based on this game's moneyline, the 49ers have an implied win probability of 56.5%.

49ers Stats (2024)

San Francisco's Key Players

Offense

• Brock Purdy passed for 3,864 yards last year (to rank 10th in the NFL), with 20 touchdowns and 12 interceptions. He completed 65.9% of his attempts while averaging 257.6 yards per game and 8.5 per attempt.
• Purdy also rushed for five touchdowns and 323 yards.
• George Kittle had 78 catches for 1,106 yards and eight receiving touchdowns. He was targeted 94 times and averaged 5.2 receptions per game over 15 games played.
• Last year over 14 games with the Commanders, Brian Robinson Jr. racked up 799 rushing yards and scored eight rushing touchdowns. He averaged 57.1 yards per game and 4.3 per attempt (23rd in the NFL).
• Robinson's stat sheet included 20 receptions (1.4 per game) on 25 targets for 159 yards (11.4 per game), though he did not score a touchdown in the passing game.
• Jauan Jennings had 975 receiving yards and six touchdowns from 77 receptions on 113 targets.

Defense

• Fred Warner's 2024 output included 131 tackles, five TFL, one sack, and two interceptions in 17 games.
• Nick Bosa had nine sacks in addition to his 15 TFL, 52 tackles, and one interception over 13 games.
• Deommodore Lenoir intercepted two passes on top of 85 tackles, two TFL, and nine passes defended during the 2024 campaign.
• Jason Pinnock's stat sheet for the Giants included 85 tackles, four TFL, three sacks, and one pass defended in 16 games

Seattle Betting Info

• Seattle went 6-10-1 ATS last year.
• The Seahawks had an ATS record of 4-5-1 as underdogs of 1.5 points or greater last year.
• Seattle games hit the over nine out of 17 times last season.
• The Seahawks were underdogs in 11 games last season and won five (45.5%) of those contests.
• Seattle had a record of 3-5 when it was set as an underdog of +110 or more by sportsbooks last season.
• The moneyline for this contest implies a 47.6% chance of a victory for the Seahawks.

Seahawks Stats (2024)

Seattle's Key Players

Offense

• For the Vikings, Sam Darnold averaged 7.9 passing yards per attempt (sixth in NFL) and 254.1 yards per game last season, completing 66.2% of his passes for 4,319 total yards (fifth in NFL) and 35 TDs (fifth in NFL) with 12 INTs in 17 games.
• Darnold also ran for one TD and 212 yards.
• Jaxon Smith-Njigba had 1,130 yards receiving and six TDs on 100 catches (ninth in the NFL), and was targeted 137 times.
• Zach Charbonnet rushed for eight TDs last season and totaled 569 rushing yards (33.5 per game and 4.2 per attempt).
• In addition to his rushing stats, Charbonnet hauled in 42 passes (on 52 targets) for 340 yards with one receiving TD. He averaged 20 receiving yards per game.
• Kenneth Walker III had 573 rushing yards and seven rushing TDs, averaging 52.1 yards per game and 3.7 per carry (40th in the NFL).
• Walker also had 299 receiving yards (27.2 per game) on 46 catches (4.2 per game). He was targeted 53 times and caught one TD pass.

Defense

• Leonard Williams' output in 2024 included 64 tackles, 16 TFL, 11 sacks, and one interception over 15 games.
• Julian Love posted 106 tackles, three TFL, and three interceptions.
• During the 2024 campaign, Ernest Jones had 138 tackles, four TFL, 0.5 sacks, and one interception in 16 games.
• Devon Witherspoon had one sack plus six TFL and 98 tackles over 17 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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