49ers vs. Saints 2025 Prediction, Odds, Picks - Sep 14

The San Francisco 49ers (1-0) are considered favorites (-3) according to the oddsmakers ahead of their game versus the New Orleans Saints (0-1) on September 14, 2025, starting at 1 p.m. ET, airing on FOX. An over/under of 40.5 points has been established for the matchup.

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49ers vs. Saints Odds & Betting Lines

49ers vs. Saints Prediction & Pick

• Pick ATS: Saints (+3)
  
• Pick OU: Over (40.5)
  
• Prediction: 49ers 23 - Saints 22

How to Watch San Francisco vs. New Orleans

• Game date: Sunday, September 14, 2025
• Time: 1 p.m. ET
• Venue: Caesars Superdome
• Location: New Orleans, Louisiana
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

49ers vs. Saints Recent Matchups

• Over their last two meetings, San Francisco has put up two wins versus New Orleans.
• New Orleans has been outpaced by 15 points in its last two tilts versus San Francisco.

San Francisco Betting Info

• San Francisco went 5-12-0 ATS last season.
• As 3-point favorites or greater, the 49ers went 5-5 against the spread last year.
• A total of 10 San Francisco games last season went over the point total.
• The 49ers went 6-7 in games they were listed as the moneyline favorite last season (winning 46.2% of those games).
• San Francisco went 5-4 last year (winning 55.6% of its games) when it played as a moneyline favorite of -166 or shorter.
• The implied moneyline probability in this matchup gives the 49ers a 62.4% chance to win.

49ers Stats (2024)

San Francisco's Key Players

Offense

• In 15 games played last year, Brock Purdy amassed 3,864 passing yards (10th-best in the NFL), while throwing 20 touchdowns against 12 interceptions and completing 65.9% of his attempts.
• He added 323 yards on the ground, with five rushing touchdowns. He averaged 21.5 yards per game and 4.9 per attempt.
• Brian Robinson Jr. scored eight rushing touchdowns, while totaling 799 rushing yards (4.3 per attempt and 57.1 per game).
• Robinson added 20 receptions (1.4 per game) for 159 yards (11.4 per game), without a receiving touchdown. He was targeted 25 times in the passing game.
• Jauan Jennings registered 975 receiving yards and six touchdowns on 77 receptions while being targeted 113 times last season.
• In 10 games with the Jaguars last season, Mac Jones had 1,672 passing yards, while throwing eight touchdowns against eight interceptions while completing 65.3% of his passes.
• Jones also had one rushing touchdown and 92 rushing yards.

Defense

• Fred Warner had one sack to go with five TFL, 131 tackles, and two interceptions over 17 games in 2024.
• Nick Bosa had one interception on top of 52 tackles, 15 TFL, nine sacks, and one pass defended.
• Deommodore Lenoir had 85 tackles, two TFL, and two interceptions in the 2024 season.
• Jason Pinnock's stats for the Giants included 85 tackles, four TFL, three sacks, and one pass defended in 16 games

New Orleans Betting Info

• New Orleans went 7-10-0 ATS last year.
• The Saints had an ATS record of 4-5 as underdogs of 3 points or greater last year.
• New Orleans games hit the over eight out of 17 times last season.
• The Saints were underdogs in 13 games last season and won three (23.1%) of those contests.
• Last season, New Orleans won two of its eight games when it was the underdog by at least +140 on the moneyline.
• The moneyline for this contest implies a 41.7% chance of a victory for the Saints.

Saints Stats (2024)

New Orleans' Key Players

Offense

• Alvin Kamara averaged 67.9 yards rushing last year (950 total yards) while scoring six rushing TDs.
• In addition to his rushing stats, Kamara had 68 catches (on 89 targets) for 543 yards, with two receiving TDs. He averaged 38.8 receiving yards per game.
• Juwan Johnson put together a 2024 stat sheet that included 50 receptions for 548 yards and three receiving TDs in 15 games. He was on the end of 66 targets and averaged 3.3 catches.
• Spencer Rattler passed for 1,317 yards last year, with four TDs and five INTs. He completed 57% of his passes, averaging 188.1 yards per game and 5.8 per attempt.
• Rattler also ran for 146 yards.
• Devaughn Vele picked up 475 yards and three TDs from 41 receptions and 55 targets for the Broncos.

Defense

• In 2024, Demario Davis amassed two sacks to go along with five TFL, 136 tackles, and one interception in 16 games.
• Alontae Taylor posted 89 tackles, seven TFL, and four sacks.
• Justin Reid had five TFL, 85 tackles, and two interceptions during the 2024 campaign for the Chiefs.
• Carl Granderson's stats for the season included 61 tackles, nine TFL, and 5.5 sacks in 17 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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