2025 NFL Week 6 Predictions, Betting Odds & TV Schedule

2025 NFL Week 6 Predictions, Betting Odds & TV Schedule

Updated Oct. 13, 2025 8:07 p.m. ET
Data Skrive

The Week 6 NFL lineup has plenty of excitement, including a matchup between the San Francisco 49ers and the Tampa Bay Buccaneers.

With Week 6 in the NFL upon us, stay on top of the most current betting odds with our preview below.

Check out the full NFL schedule on FOX Sports!

Week 6 Betting Lines & Game Info

New York Giants vs. Philadelphia Eagles

Odds & Prediction

  • Spread: Eagles (-7.5)
  • Moneyline: Eagles -422, Giants +324
  • Total: 40.5 points
  • Prediction: Eagles 28, Giants 16

How to Watch

  • Game Date: Thursday, Oct. 9
  • Game Time: 8:15 p.m. ET
  • TV Channel: Amazon Prime Video
  • Box Score
  • Location: East Rutherford, New Jersey

New York Jets vs. Denver Broncos

Odds & Prediction

  • Spread: Broncos (-7)
  • Moneyline: Broncos -391, Jets +307
  • Total: 43.5 points
  • Prediction: Broncos 34, Jets 13

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 9:30 a.m. ET
  • TV Channel: NFL Network
  • Box Score
  • Location: London, England

Miami Dolphins vs. Los Angeles Chargers

Odds & Prediction

  • Spread: Chargers (-3.5)
  • Moneyline: Chargers -200, Dolphins +165
  • Total: 45.5 points
  • Prediction: Chargers 25, Dolphins 20

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Miami Gardens, Florida

Jacksonville Jaguars vs. Seattle Seahawks

Odds & Prediction

  • Spread: Seahawks (-1.5)
  • Moneyline: Seahawks -114, Jaguars -105
  • Total: 47.5 points
  • Prediction: Jaguars 25, Seahawks 23

How to Watch

Baltimore Ravens vs. Los Angeles Rams

Odds & Prediction

  • Spread: Rams (-7)
  • Moneyline: Rams -373, Ravens +290
  • Total: 43.5 points
  • Prediction: Rams 34, Ravens 21

How to Watch

New Orleans Saints vs. New England Patriots

Odds & Prediction

  • Spread: Patriots (-3.5)
  • Moneyline: Patriots -186, Saints +152
  • Total: 45.5 points
  • Prediction: Patriots 25, Saints 20

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: New Orleans, Louisiana

Carolina Panthers vs. Dallas Cowboys

Odds & Prediction

  • Spread: Cowboys (-3)
  • Moneyline: Cowboys -164, Panthers +138
  • Total: 48.5 points
  • Prediction: Panthers 29, Cowboys 23

How to Watch

Indianapolis Colts vs. Arizona Cardinals

Odds & Prediction

  • Spread: Colts (-9.5)
  • Moneyline: Colts -463, Cardinals +353
  • Total: 45.5 points
  • Prediction: Colts 31, Cardinals 14

How to Watch

Pittsburgh Steelers vs. Cleveland Browns

Odds & Prediction

  • Spread: Steelers (-6)
  • Moneyline: Steelers -297, Browns +236
  • Total: 38 points
  • Prediction: Steelers 31, Browns 13

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 1 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Pittsburgh, Pennsylvania

Las Vegas Raiders vs. Tennessee Titans

Odds & Prediction

  • Spread: Raiders (-3.5)
  • Moneyline: Raiders -192, Titans +159
  • Total: 41.5 points
  • Prediction: Raiders 22, Titans 21

How to Watch

Green Bay Packers vs. Cincinnati Bengals

Odds & Prediction

  • Spread: Packers (-14)
  • Moneyline: Packers -1124, Bengals +700
  • Total: 44.5 points
  • Prediction: Packers 31, Bengals 16

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 4:25 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Green Bay, Wisconsin

Tampa Bay Buccaneers vs. San Francisco 49ers

Odds & Prediction

  • Spread: Buccaneers (-3.5)
  • Moneyline: Buccaneers -186, 49ers +153
  • Total: 46.5 points
  • Prediction: Buccaneers 24, 49ers 23

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 4:25 p.m. ET
  • TV Channel: CBS
  • Box Score
  • Location: Tampa, Florida

Kansas City Chiefs vs. Detroit Lions

Odds & Prediction

  • Spread: Chiefs (-2.5)
  • Moneyline: Chiefs -149, Lions +125
  • Total: 51.5 points
  • Prediction: Lions 27, Chiefs 25

How to Watch

  • Game Date: Sunday, Oct. 12
  • Game Time: 8:20 p.m. ET
  • TV Channel: NBC
  • Box Score
  • Location: Kansas City, Missouri

Atlanta Falcons vs. Buffalo Bills

Odds & Prediction

  • Spread: Bills (-3.5)
  • Moneyline: Bills -207, Falcons +171
  • Total: 49.5 points
  • Prediction: Falcons 25, Bills 22

How to Watch

  • Game Date: Monday, Oct. 13
  • Game Time: 7:15 p.m. ET
  • TV Channel: ESPN
  • Box Score
  • Location: Atlanta, Georgia

Washington Commanders vs. Chicago Bears

Odds & Prediction

  • Spread: Commanders (-5.5)
  • Moneyline: Commanders -259, Bears +210
  • Total: 49.5 points
  • Prediction: Commanders 32, Bears 18

How to Watch

  • Game Date: Monday, Oct. 13
  • Game Time: 8:15 p.m. ET
  • TV Channel: ABC
  • Box Score
  • Location: Landover, Maryland

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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