2025 NFL Week 6 Predictions, Betting Odds & TV Schedule

The Week 6 NFL lineup has plenty of excitement, including a matchup between the San Francisco 49ers and the Tampa Bay Buccaneers.

With Week 6 in the NFL upon us, stay on top of the most current betting odds with our preview below.

Check out the full NFL schedule on FOX Sports!

Week 6 Betting Lines & Game Info

New York Giants vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-7.5)
• Moneyline: Eagles -422, Giants +324
• Total: 40.5 points
• Prediction: Eagles 28, Giants 16

How to Watch

• Game Date: Thursday, Oct. 9
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Box Score
• Location: East Rutherford, New Jersey

New York Jets vs. Denver Broncos

Odds & Prediction

• Spread: Broncos (-7)
• Moneyline: Broncos -391, Jets +307
• Total: 43.5 points
• Prediction: Broncos 34, Jets 13

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 9:30 a.m. ET
• TV Channel: NFL Network
• Box Score
• Location: London, England

Miami Dolphins vs. Los Angeles Chargers

Odds & Prediction

• Spread: Chargers (-3.5)
• Moneyline: Chargers -200, Dolphins +165
• Total: 45.5 points
• Prediction: Chargers 25, Dolphins 20

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Miami Gardens, Florida

Jacksonville Jaguars vs. Seattle Seahawks

Odds & Prediction

• Spread: Seahawks (-1.5)
• Moneyline: Seahawks -114, Jaguars -105
• Total: 47.5 points
• Prediction: Jaguars 25, Seahawks 23

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Jacksonville, Florida

Baltimore Ravens vs. Los Angeles Rams

Odds & Prediction

• Spread: Rams (-7)
• Moneyline: Rams -373, Ravens +290
• Total: 43.5 points
• Prediction: Rams 34, Ravens 21

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Baltimore, Maryland

New Orleans Saints vs. New England Patriots

Odds & Prediction

• Spread: Patriots (-3.5)
• Moneyline: Patriots -186, Saints +152
• Total: 45.5 points
• Prediction: Patriots 25, Saints 20

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: New Orleans, Louisiana

Carolina Panthers vs. Dallas Cowboys

Odds & Prediction

• Spread: Cowboys (-3)
• Moneyline: Cowboys -164, Panthers +138
• Total: 48.5 points
• Prediction: Panthers 29, Cowboys 23

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Charlotte, North Carolina

Indianapolis Colts vs. Arizona Cardinals

Odds & Prediction

• Spread: Colts (-9.5)
• Moneyline: Colts -463, Cardinals +353
• Total: 45.5 points
• Prediction: Colts 31, Cardinals 14

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Indianapolis, Indiana

Pittsburgh Steelers vs. Cleveland Browns

Odds & Prediction

• Spread: Steelers (-6)
• Moneyline: Steelers -297, Browns +236
• Total: 38 points
• Prediction: Steelers 31, Browns 13

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Pittsburgh, Pennsylvania

Las Vegas Raiders vs. Tennessee Titans

Odds & Prediction

• Spread: Raiders (-3.5)
• Moneyline: Raiders -192, Titans +159
• Total: 41.5 points
• Prediction: Raiders 22, Titans 21

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Paradise, Nevada

Green Bay Packers vs. Cincinnati Bengals

Odds & Prediction

• Spread: Packers (-14)
• Moneyline: Packers -1124, Bengals +700
• Total: 44.5 points
• Prediction: Packers 31, Bengals 16

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Green Bay, Wisconsin

Tampa Bay Buccaneers vs. San Francisco 49ers

Odds & Prediction

• Spread: Buccaneers (-3.5)
• Moneyline: Buccaneers -186, 49ers +153
• Total: 46.5 points
• Prediction: Buccaneers 24, 49ers 23

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Tampa, Florida

Kansas City Chiefs vs. Detroit Lions

Odds & Prediction

• Spread: Chiefs (-2.5)
• Moneyline: Chiefs -149, Lions +125
• Total: 51.5 points
• Prediction: Lions 27, Chiefs 25

How to Watch

• Game Date: Sunday, Oct. 12
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Kansas City, Missouri

Atlanta Falcons vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-3.5)
• Moneyline: Bills -207, Falcons +171
• Total: 49.5 points
• Prediction: Falcons 25, Bills 22

How to Watch

• Game Date: Monday, Oct. 13
• Game Time: 7:15 p.m. ET
• TV Channel: ESPN
• Box Score
• Location: Atlanta, Georgia

Washington Commanders vs. Chicago Bears

Odds & Prediction

• Spread: Commanders (-5.5)
• Moneyline: Commanders -259, Bears +210
• Total: 49.5 points
• Prediction: Commanders 32, Bears 18

How to Watch

• Game Date: Monday, Oct. 13
• Game Time: 8:15 p.m. ET
• TV Channel: ABC
• Box Score
• Location: Landover, Maryland

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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