2025 NFL Week 4 Predictions, Betting Odds & TV Schedule

The matchups in a Week 4 NFL schedule that shouldn't be missed include the Baltimore Ravens taking on the Kansas City Chiefs at GEHA Field at Arrowhead Stadium.

With Week 4 in the NFL upon us, stay on top of the latest betting odds with our preview below.

Check out the full NFL schedule on FOX Sports!

Week 4 Betting Lines & Game Info

Arizona Cardinals vs. Seattle Seahawks

Odds & Prediction

• Spread: Seahawks (-1.5)
• Moneyline: Seahawks -128, Cardinals +109
• Total: 43.5 points
• Prediction: Cardinals 24, Seahawks 21

How to Watch

• Game Date: Thursday, Sept. 25
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Box Score
• Location: Glendale, Arizona

Pittsburgh Steelers vs. Minnesota Vikings

Odds & Prediction

• Spread: Vikings (-2.5)
• Moneyline: Vikings -146, Steelers +123
• Total: 40.5 points
• Prediction: Vikings 24, Steelers 20

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 9:30 a.m. ET
• TV Channel: NFL Network
• Box Score
• Location: Dublin, Ireland

Atlanta Falcons vs. Washington Commanders

Odds & Prediction

• Spread: Falcons (-2.5)
• Moneyline: Falcons -147, Commanders +122
• Total: 43.5 points
• Prediction: Commanders 27, Falcons 23

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Atlanta, Georgia

New England Patriots vs. Carolina Panthers

Odds & Prediction

• Spread: Patriots (-5.5)
• Moneyline: Patriots -254, Panthers +204
• Total: 43.5 points
• Prediction: Patriots 26, Panthers 20

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Foxborough, Massachusetts

Tampa Bay Buccaneers vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-3.5)
• Moneyline: Eagles -192, Buccaneers +161
• Total: 44.5 points
• Prediction: Eagles 25, Buccaneers 24

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Tampa, Florida

Detroit Lions vs. Cleveland Browns

Odds & Prediction

• Spread: Lions (-10)
• Moneyline: Lions -588, Browns +422
• Total: 44.5 points
• Prediction: Lions 39, Browns 9

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Detroit, Michigan

New York Giants vs. Los Angeles Chargers

Odds & Prediction

• Spread: Chargers (-6)
• Moneyline: Chargers -292, Giants +235
• Total: 43.5 points
• Prediction: Chargers 27, Giants 14

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: East Rutherford, New Jersey

Houston Texans vs. Tennessee Titans

Odds & Prediction

• Spread: Texans (-7.5)
• Moneyline: Texans -418, Titans +321
• Total: 39.5 points
• Prediction: Texans 30, Titans 14

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Houston, Texas

Buffalo Bills vs. New Orleans Saints

Odds & Prediction

• Spread: Bills (-14.5)
• Moneyline: Bills -1493, Saints +850
• Total: 48.5 points
• Prediction: Bills 34, Saints 14

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Orchard Park, New York

Los Angeles Rams vs. Indianapolis Colts

Odds & Prediction

• Spread: Rams (-3.5)
• Moneyline: Rams -187, Colts +156
• Total: 49.5 points
• Prediction: Rams 29, Colts 17

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Inglewood, California

San Francisco 49ers vs. Jacksonville Jaguars

Odds & Prediction

• Spread: 49ers (-3)
• Moneyline: 49ers -175, Jaguars +144
• Total: 45.5 points
• Prediction: 49ers 28, Jaguars 19

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Santa Clara, California

Las Vegas Raiders vs. Chicago Bears

Odds & Prediction

• Spread: Raiders (-1.5)
• Moneyline: Raiders -128, Bears +108
• Total: 48.5 points
• Prediction: Raiders 22, Bears 20

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Paradise, Nevada

Kansas City Chiefs vs. Baltimore Ravens

Odds & Prediction

• Spread: Ravens (-2.5)
• Moneyline: Ravens -149, Chiefs +125
• Total: 48.5 points
• Prediction: Ravens 24, Chiefs 23

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Kansas City, Missouri

Dallas Cowboys vs. Green Bay Packers

Odds & Prediction

• Spread: Packers (-6.5)
• Moneyline: Packers -334, Cowboys +267
• Total: 46.5 points
• Prediction: Packers 29, Cowboys 18

How to Watch

• Game Date: Sunday, Sept. 28
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Arlington, Texas

Miami Dolphins vs. New York Jets

Odds & Prediction

• Spread: Dolphins (-2.5)
• Moneyline: Dolphins -152, Jets +127
• Total: 44 points
• Prediction: Dolphins 24, Jets 19

How to Watch

• Game Date: Monday, Sept. 29
• Game Time: 7:15 p.m. ET
• TV Channel: ESPN
• Box Score
• Location: Miami Gardens, Florida

Denver Broncos vs. Cincinnati Bengals

Odds & Prediction

• Spread: Broncos (-7.5)
• Moneyline: Broncos -472, Bengals +361
• Total: 44.5 points
• Prediction: Broncos 29, Bengals 19

How to Watch

• Game Date: Monday, Sept. 29
• Game Time: 8:15 p.m. ET
• TV Channel: ABC
• Box Score
• Location: Denver, Colorado

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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