Yankees vs. White Sox Prediction, Odds, Picks - September 23

Ben Rice and the New York Yankees will take on the Chicago White Sox and Lenyn Sosa on Tuesday at 7:05 p.m. ET, at Yankee Stadium. The Yankees are favored in this one, at -242, while the underdog White Sox have +196 odds to upset. New York is a 1.5-run favorite (at -119 odds). The total for the contest is listed at 9 runs.

Here's everything you need to know from a betting perspective on the Yankees-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. White Sox Highlights | MLB on FOX

Check out the best highlights between the San Diego Padres and the Chicago White Sox.

Yankees vs. White Sox Game Information & Odds

• When: Tuesday, September 23, 2025 at 7:05 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: YES and CHSN

Yankees vs. White Sox Prediction

• Score Prediction: Yankees 5, White Sox 3
• Total Prediction: Under 9 runs
• Win Probabilities: Yankees 60%, White Sox 40%

Yankees vs. White Sox Betting Insights

• The Yankees have won 78, or 58.6%, of the 133 games they've played as favorites this season.
• New York has a record of 8-6, a 57.1% win rate, when favored by -242 or more by oddsmakers this season.
• The moneyline for this contest implies a 70.8% chance of a victory for the Yankees.
• The White Sox have been victorious in 57, or 37.3%, of the 153 contests they have been chosen as underdogs in this season.
• Chicago has a win-loss record of 2-28 when favored by +196 or worse by bookmakers this year.
• The White Sox have an implied victory probability of 33.8% according to the moneyline set for this matchup.

Yankees Recent Betting Performance

• The Yankees played as the moneyline favorite in nine of their last 10 games, and they went 7-2 in those matchups.
• In their last 10 matchups (all had set totals), the Yankees combined with their opponents to hit the over on the total three times.
• The Yankees' ATS record is 6-4-0 over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge is the bat to watch in the Yankees lineup, leading the team in batting average (.326), home runs (49), and RBI (105).
• In all of the majors, Judge is fourth in home runs and ninth in RBI.
• Cody Bellinger is hitting .271 with 25 doubles, five triples, 29 home runs and 51 walks.
• Bellinger is 29th in homers and 14th in RBI among all hitters in baseball.
• Bellinger carries a two-game streak with at least one hit into this contest. In his last five games he is hitting .211 with a home run, three walks and three RBIs.
• Trent Grisham is batting .238 with nine doubles, a triple, 33 home runs and 75 walks.
• Jazz Chisholm is hitting .242 with 14 doubles, a triple, 31 home runs and 57 walks.
• Chisholm has recorded at least one hit in four games in a row. In his last five games he is hitting .211 with a double, two home runs, a walk and four RBIs.

Yankees Team Props

White Sox Recent Betting Performance

• In nine games over the last 10 matchups when set as underdogs by oddsmakers, the White Sox had a record of 2-7.
• In their last 10 games with a total, the White Sox and their opponents have failed to hit the over eight times.
• The White Sox have five wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas is batting .230 with 32 doubles, two triples, 15 home runs and 52 walks.
• In all of the majors, Vargas ranks 136th in homers and 133rd in RBI.
• Vargas has collected a hit in three straight games. In his last five games he is hitting .211 with a double, a home run, two walks and four RBIs.
• Sosa proven to be a run producer as he leads his team with 21 home runs and 71 RBI, with a team-leading .259 batting average.
• Sosa is 67th among all hitters in the majors in homers, and 78th in RBI.
• Chase Meidroth is hitting .265 with 15 doubles, five home runs and 45 walks.
• Mike Tauchman has 17 doubles, a triple, nine home runs and 45 walks while hitting .263.

White Sox Team Props

Padres vs. White Sox Highlights | MLB on FOX

Check out the best highlights between the San Diego Padres and the Chicago White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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