Yankees vs. Padres Prediction, Odds, Picks - May 6

The San Diego Padres and Luis Arraez hit the field against Paul Goldschmidt and the New York Yankees on Tuesday at Yankee Stadium. The favored Yankees have -127 moneyline odds against the underdog Padres, who are listed at +107. New York is favored on the run line (-1.5 with +168 odds). An 8-run total has been set for this matchup.

Here's everything you need from a betting perspective on the Yankees-Padres game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Padres vs. Yankees Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and the New York Yankees.

Yankees vs. Padres Game Information & Odds

• When: Tuesday, May 6, 2025 at 7:05 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: TBS, YES, and SDPA

Yankees vs. Padres Prediction

• Score Prediction: Yankees 5, Padres 4
• Total Prediction: Under 8 runs
• Win Probabilities: Yankees 52%, Padres 48%

Yankees vs. Padres Betting Insights

• The Yankees have been favorites in 28 games this season and won 17 (60.7%) of those contests.
• New York has a record of 16-10, a 61.5% win rate, when favored by -127 or more by oddsmakers this season.
• The moneyline for this contest implies a 55.9% chance of a victory for the Yankees.
• The Padres have been underdogs in 17 games this season and have come away with the win 10 times (58.8%) in those contests.
• San Diego has a mark of 5-5 in contests where bookmakers favor it by +107 or worse on the moneyline.
• The Padres have an implied victory probability of 48.3% according to the moneyline set by oddsmakers for this matchup.

Yankees Recent Betting Performance

• The Yankees went 4-5 over the nine games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Yankees combined with their opponents to hit the over on the run total three times.
• The Yankees have put together a 4-6-0 record against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge's 11 round-trippers and 33 RBI both lead the Yankees, on top of his team-high .414 average.
• Including all MLB hitters, Judge ranks first in batting average, first in on-base percentage, and first in slugging.
• Goldschmidt is hitting .353 with eight doubles, three home runs and 10 walks.
• Goldschmidt is 130th in home runs and 68th in RBI among all hitters in MLB.
• Goldschmidt has two straight games with at least one hit. In his last five games he is hitting .300 with two home runs, a walk and five RBIs.
• Ben Rice is batting .255 with six doubles, a triple, eight home runs and 14 walks.
• Trent Grisham is hitting .298 with a double, nine home runs and 10 walks.
• Grisham brings a three-game streak with at least one hit into this one. In his last five games he is hitting .313 with a home run, three walks and two RBIs.

Yankees Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in six of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Padres and their opponents have combined to hit the over three times.
• The Padres have a record of 6-4-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. leads the Padres in home runs (eight), runs batted in (18) and has posted a team-high batting average of .317.
• Among all hitters in the big leagues, Tatis' home run total is 20th and his RBI tally is 53rd.
• Manny Machado is batting .294 with 12 doubles, three home runs and 13 walks.
• Among all major league hitters, Machado is 130th in home runs and 81st in RBI.
• Arraez is hitting .297 with four doubles, a triple, three home runs and six walks.
• Xander Bogaerts is hitting .254 with nine doubles, a home run and 16 walks.

Padres Team Props

Padres vs. Yankees Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and the New York Yankees.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

New York Yankees

San Diego Padres