Yankees vs. Astros Prediction, Odds, Picks - September 4

Trent Grisham and the New York Yankees take on Yordan Alvarez and the Houston Astros on Thursday at 7:40 p.m. ET, in the final of a three-game series at Daikin Park. The Yankees are -148 moneyline favorites in this matchup against the Astros (+123). New York (-1.5) is the favorite on the run line. The over/under is 9 runs for this matchup.

Here's everything you need to know from a betting perspective on the Yankees-Astros game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Yankees vs. White Sox Highlights | MLB on FOX

Check out the best moments between the New York Yankees and Chicago White Sox.

Yankees vs. Astros Game Information & Odds

• When: Thursday, September 4, 2025 at 7:40 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: MLB Network, SCHN, and YES

Yankees vs. Astros Prediction

• Score Prediction: Yankees 6, Astros 5
• Total Prediction: Over 9 runs
• Win Probabilities: Yankees 50%, Astros 50%

Yankees vs. Astros Betting Insights

• This season, the Yankees have been favored 117 times and won 67, or 57.3%, of those games.
• This season New York has won 48 of its 76 games, or 63.2%, when favored by at least -148 on the moneyline.
• The Yankees have a 59.7% chance to win this game based on the implied probability of the moneyline.
• The Astros have won in 27, or 58.7%, of the 46 contests they have been named as odds-on underdogs this year.
• Houston has a win-loss record of 8-4 when favored by +123 or worse by oddsmakers this year.
• The Astros have an implied victory probability of 44.8% according to the moneyline set for this matchup.

Yankees Recent Betting Performance

• The Yankees were the moneyline favorite in each of their last 10 games, and finished 8-2 in those matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Yankees and their opponents combined to hit the over six times.
• The Yankees are 8-2-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge is the bat to watch in the Yankees lineup, leading the team in batting average (.323), home runs (43), and RBI (97).
• Judge's home runs rank him fourth in MLB, and he ranks seventh in RBI.
• Judge has collected a hit in four games in a row. In his last five games he is hitting .333 with a double, two home runs, four walks and two RBIs.
• Cody Bellinger has 23 doubles, five triples, 27 home runs and 43 walks while hitting .278.
• Bellinger is 24th in home runs and 19th in RBI among all hitters in MLB.
• Bellinger carries a four-game streak with at least one hit into this matchup. During his last five outings he is batting .182 with a double, a home run, two walks and five RBIs.
• Grisham is batting .246 with nine doubles, a triple, 29 home runs and 68 walks.
• Jazz Chisholm is hitting .243 with 13 doubles, a triple, 28 home runs and 54 walks.
• Chisholm has recorded at least one hit in two games in a row. During his last five outings he is batting .263 with a double, two home runs, four walks and four RBIs.

Yankees Team Props

Astros Recent Betting Performance

• In three games as underdogs over the last 10 matchups, the Astros have a record of 1-2.
• The Astros and their opponents have combined to hit the over two times in their last 10 games with a total.
• Over their last 10 games, the Astros are 5-5-0 against the spread.

Astros Recent Stats

Astros Player Insights

• Jose Altuve paces the Astros with 24 long balls.
• Among all hitters in the big leagues, Altuve is 39th in home runs and 61st in RBI.
• Jeremy Pena has a club-best .306 batting average.
• Pena ranks 116th in homers and 128th in RBI among all major league hitters this year.
• Yainer Diaz is hitting .253 with 19 doubles, a triple, 18 home runs and 19 walks.
• Christian Walker has driven in the most runs for the Astros with 74 runs batted in.

Astros Team Props

Yankees vs. White Sox Highlights | MLB on FOX

Check out the best moments between the New York Yankees and Chicago White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Houston Astros

New York Yankees