Twins vs. White Sox Prediction, Odds, Picks - September 4

Byron Buxton and the Minnesota Twins will try to defeat Andrew Benintendi and the Chicago White Sox at Target Field on Thursday at 7:40 p.m. ET. The favored Twins have -149 moneyline odds to win against the underdog White Sox, who are listed at +125. Minnesota is the favorite on the run line (-1.5). The over/under is 8.5 runs for this contest (with -117 odds to go over and -103 odds to go under).

Check out everything you need from a betting perspective on the Twins-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Twins Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Minnesota Twins.

Twins vs. White Sox Game Information & Odds

• When: Thursday, September 4, 2025 at 7:40 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and CHSN

Twins vs. White Sox Prediction

• Score Prediction: Twins 6, White Sox 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Twins 52%, White Sox 48%

Twins vs. White Sox Betting Insights

• This season, the Twins have been favored 80 times and won 38, or 47.5%, of those games.
• Minnesota has entered 30 games this season favored by -149 or more and is 17-13 in those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Twins have a 59.8% chance to win.
• The White Sox have been chosen as underdogs in 138 games this year and have walked away with the win 51 times (37%) in those games.
• Chicago has a win-loss record of 34-65 when favored by +125 or worse by bookmakers this year.
• Sportsbooks have implied with the moneyline set for this matchup that the White Sox have a 44.4% chance of pulling out a win.

Twins Recent Betting Performance

• The Twins were the moneyline favorite in five of their last 10 games, and they went 1-4 in those matchups.
• In their last 10 outings, the Twins and their opponents combined to hit the over on the run total eight times (all 10 games had set totals).
• The Twins' ATS record is 4-6-0 over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Buxton leads the Twins in home runs (29), runs batted in (72) and has accumulated a team-best batting average of .273.
• Including all MLB batters, Buxton is 38th in batting average, 70th in on-base percentage, and fifth in slugging.
• Buxton carries a seven-game hitting streak into this matchup. During his last 10 games he is hitting .282 with three doubles, two triples, four home runs, three walks and 10 RBIs.
• Trevor Larnach has 20 doubles, a triple, 16 home runs and 46 walks while hitting .254.
• Larnach ranks 100th in home runs and 108th in RBI in the majors.
• Larnach has five games in a row with at least one hit. During his last five outings he is hitting .526 with a double, a walk and four RBIs.
• Brooks Lee is hitting .242 with 13 doubles, a triple, 14 home runs and 26 walks.
• Ryan Jeffers is hitting .262 with 24 doubles, nine home runs and 47 walks.

Twins Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won five of those contests.
• The White Sox and their opponents have combined to hit the over six times in their last 10 games with a total.
• The White Sox have won six of their last 10 games against the spread.

White Sox Recent Stats

White Sox Player Insights

• Benintendi is hitting .244 with 15 doubles, two triples, 17 home runs and 35 walks.
• Among all hitters in the big leagues, Benintendi ranks 92nd in home runs and 114th in RBI.
• Lenyn Sosa proven to be a run producer as he paces his team with 19 home runs and 62 runs batted in, with a team-best .265 batting average.
• Among all MLB hitters, Sosa ranks 69th in homers and 84th in RBI.
• Chase Meidroth is batting .251 with 14 doubles, four home runs and 38 walks.
• Mike Tauchman has 15 doubles, a triple, eight home runs and 40 walks while hitting .271.

White Sox Team Props

White Sox vs. Twins Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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