Twins vs. White Sox Prediction, Odds, Picks - September 1

Byron Buxton and the Minnesota Twins play Lenyn Sosa and the Chicago White Sox at Target Field on Monday. First pitch is at 2:10 p.m. ET. The Twins are the favorite in this one, at -188, while the underdog White Sox have +156 odds to upset. Minnesota is a 1.5-run favorite (at +109 odds). The over/under is 9.5 runs for the contest.

Here's everything you need from a betting perspective on the Twins-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. White Sox Game Information & Odds

• When: Monday, September 1, 2025 at 2:10 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and CHSN

Twins vs. White Sox Prediction

• Score Prediction: Twins 5, White Sox 4
• Total Prediction: Under 9.5 runs
• Win Probabilities: Twins 53%, White Sox 47%

Twins vs. White Sox Betting Insights

• The Twins have been favorites in 77 games this season and won 38 (49.4%) of those contests.
• Minnesota is 8-5 this season when entering a game favored by -188 or more on the moneyline.
• The sportsbooks' moneyline implies a 65.3% chance of a victory for the Twins.
• The White Sox have come away with 48 wins in the 135 contests they have been listed as the underdogs in this season.
• This season, Chicago has come away with a win 16 times in 58 chances when named as an underdog of at least +156 or longer on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the White Sox have a 39.1% chance of pulling out a win.

Twins Recent Betting Performance

• The Twins have a 2-2 record across the four games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 matchups, the Twins and their opponents combined to hit the over on the run total nine times (all 10 games had set totals).
• The Twins' ATS record is 5-5-0 over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Not only does Buxton lead the Twins in hitting with his .271 average, he also is their premier power option with 29 home runs and 70 RBI.
• Including all MLB hitters, Buxton ranks 41st in batting average, 71st in on-base percentage, and sixth in slugging.
• Buxton brings a hitting streak of four games into this matchup. In his last five games he is hitting .300 with a double, four home runs, two walks and eight RBIs.
• Trevor Larnach has 19 doubles, a triple, 16 home runs and 45 walks while batting .249.
• Larnach is 96th in homers in baseball, and 111th in RBI.
• Larnach heads into this game looking for his third game in a row with a hit. In his last five games he is batting .438 with a double, two walks and three RBIs.
• Brooks Lee is hitting .244 with 13 doubles, a triple, 14 home runs and 26 walks.
• Ryan Jeffers has 24 doubles, nine home runs and 45 walks while hitting .260.

Twins Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won four of those contests.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over six times.
• Over their last 10 games, the White Sox are 5-5-0 against the spread.

White Sox Recent Stats

White Sox Player Insights

• Andrew Benintendi is hitting .240 with 15 doubles, two triples, 15 home runs and 33 walks, while getting on base at a rate of .301.
• Benintendi is 110th in home runs and 144th in RBI among all batters in the big leagues.
• Benintendi has collected a hit in seven games in a row. During his last 10 games he is batting .324 with a double, a home run, two walks and two RBIs.
• Sosa has hit 18 home runs with 61 RBI while batting .269. Those numbers are pace the clubhouse.
• Sosa is 75th among all hitters in the big leagues in home runs, and 83rd in RBI.
• Chase Meidroth is hitting .253 with 14 doubles, three home runs and 38 walks.
• Mike Tauchman is batting .272 with 14 doubles, a triple, eight home runs and 39 walks.

White Sox Team Props

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Check out the best moments between the New York Yankees and the Chicago White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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