Twins vs. Orioles Prediction, Odds, Picks - May 6

Byron Buxton and the Minnesota Twins will play Ryan O'Hearn and the Baltimore Orioles on Tuesday at Target Field, at 7:40 p.m. ET. The Orioles have been listed as +144 moneyline underdogs in this matchup against the favorite Twins (-172). Minnesota is a 1.5-run favorite (at +120 odds). The over/under is 9 runs for the game (with -106 odds on the over and -114 odds to go under).

Here's everything you need from a betting perspective on the Twins-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Orioles Game Information & Odds

• When: Tuesday, May 6, 2025 at 7:40 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and MASN

Twins vs. Orioles Prediction

• Score Prediction: Twins 4, Orioles 3
• Total Prediction: Under 9 runs
• Win Probabilities: Twins 58%, Orioles 42%

Twins vs. Orioles Betting Insights

• This season, the Twins have won 11 out of the 23 games, or 47.8%, in which they've been favored.
• Minnesota has entered seven games this season favored by -172 or more and is 5-2 in those contests.
• The implied probability of a win from the Twins, based on the moneyline, is 63.2%.
• The Orioles have been underdogs in 14 games this season and have come away with the win six times (42.9%) in those contests.
• Baltimore has played as an underdog of +144 or more just one time this year and came away with a loss in that game.
• The Orioles have an implied victory probability of 41% according to the moneyline set by oddsmakers for this matchup.

Twins Recent Betting Performance

• The Twins have a 3-2 record over the five games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Twins combined with their opponents to hit the over on the run total three times.
• The Twins have a 7-3-0 record against the spread over their past 10 games.

Twins Recent Stats

Twins Player Insights

• The Twins leader in both batting average and homers is Buxton, who comes into the contest hitting .260 and has left the yard seven times while driving in 18 runs this season.
• Including all MLB batters, Buxton ranks 64th in batting average, 118th in on-base percentage, and 34th in slugging.
• Buxton brings a hitting streak of five games into this game. In his last five games he is batting .364 with a home run, a walk and an RBI.
• Ty France has made the most of his opportunities as he leads his team with 19 RBI.
• Among all MLB hitters, France ranks 130th in homers and 43rd in RBI.
• Trevor Larnach is batting .230 with two doubles, four home runs and 16 walks.
• Larnach has at least one base hit in three straight games. During his last five outings he is hitting .263 with three walks and two RBIs.
• Ryan Jeffers has eight doubles, two home runs and 10 walks while batting .278.
• Jeffers takes a three-game streak with at least one hit into this one. In his last five games he is hitting .375 with a double, a home run, a walk and three RBIs.

Twins Team Props

Orioles Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Orioles have a record of 2-3.
• In their last 10 games with a total, the Orioles and their opponents have combined to hit the over two times.
• The Orioles have four wins against the spread in their last 10 chances.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins has posted a team-leading seven home runs and has driven in 21 runs.
• In all of the majors, Mullins ranks 30th in homers and 32nd in RBI.
• O'Hearn's seven home runs pace his team.
• O'Hearn ranks 30th overall in homers and 107th in RBI this season.
• Adley Rutschman is batting .216 with four doubles, four home runs and 17 walks.
• Jackson Holliday is hitting .273 with a double, a triple, four home runs and seven walks.

Orioles Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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