Twins vs. Giants Prediction, Odds, Picks - May 11

Updated May. 11, 2025 2:00 p.m. ET

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Byron Buxton and the Minnesota Twins take on Matt Chapman and the San Francisco Giants on Sunday at 2:10 p.m. ET. The favored Twins have -163 moneyline odds against the underdog Giants, who are listed at +137. Minnesota (-1.5) is the favorite on the run line. The contest's total has been listed at 8.5 runs.

Here is everything you need from a betting perspective on the Twins-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Heliot Ramos gives Giants lead over Twins with solo home run

Heliot Ramos gave the San Francisco Giants the lead over the Minnesota Twins with a solo home run.

Twins vs. Giants Game Information & Odds

• When: Sunday, May 11, 2025 at 2:10 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and NBCS-BA

Twins vs. Giants Prediction

• Score Prediction: Twins 4, Giants 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Twins 51%, Giants 49%

Twins vs. Giants Betting Insights

• The Twins have won 14, or 53.8%, of the 26 games they've played as favorites this season.
• Minnesota has entered nine games this season favored by -163 or more and is 7-2 in those contests.
• The moneyline for this contest implies a 62% chance of a victory for the Twins.
• The Giants have won in nine, or 56.2%, of the 16 contests they have been named as odds-on underdogs this year.
• This year, San Francisco has won one of four games when listed as at least +137 or worse on the moneyline.
• The moneyline set for this matchup implies the Giants have a 42.2% chance of walking away with the win.

FINAL (10)

SF 6 · MIN 7

MLB

RUN LINE

TO WIN

TOTAL

San Francisco Giants

SF

+1.5

+138

O 8.5

Minnesota Twins

MIN

-1.5

-164

U 8.5

Twins Recent Betting Performance

• The Twins were the moneyline favorite in five of their last 10 games, and they finished 3-2 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Twins and their opponents combined to go over the total two times.
• The Twins' ATS record is 7-3-0 over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Buxton paces the Twins with nine home runs and 25 runs batted in, while racking up a team-best batting average of .271.
• In all of MLB, Buxton is 12th in home runs and 21st in RBI.
• Ty France is batting .269 with eight doubles, three home runs and 10 walks.
• France is 148th in homers and 52nd in RBI on the year.
• Trevor Larnach is batting .232 with three doubles, six home runs and 16 walks.
• Larnach has at least one base hit in three straight games. In his last five games he is hitting .250 with a double, two home runs and four RBIs.
• Harrison Bader is batting .290 with five doubles, four home runs and 12 walks.
• Bader takes a two-game streak with at least one hit into this one. During his last five outings he is batting .400 with two doubles, a home run, four walks and three RBIs.

Twins Team Props

Giants Recent Betting Performance

• The Giants have played as underdogs in four of their past 10 games and have gone 2-2 in those contests.
• In their last 10 games with a total, the Giants and their opponents have failed to hit the over five times.
• The Giants have a record of 5-5-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee leads the team in batting average with a high-water mark of .287.
• Lee is 111th in homers and 35th in RBI among all batters in MLB.
• Chapman has put his power on display as he paces his team with eight home runs.
• Chapman ranks 27th among all hitters in MLB in home runs, and 29th in RBI.
• Wilmer Flores leads the Giants with 33 runs batted in.
• Heliot Ramos has 10 doubles, six home runs and 12 walks while hitting .268.

Giants Team Props

Heliot Ramos gives Giants lead over Twins with solo home run

Heliot Ramos gave the San Francisco Giants the lead over the Minnesota Twins with a solo home run.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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MLB - San Francisco Giants vs. Minnesota Twins - 05/11/2025

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