Tigers vs. Guardians Prediction, Odds, Picks - May 25

The Detroit Tigers and Riley Greene will take the field against the Cleveland Guardians and Steven Kwan on Sunday at 11:35 a.m. ET, in the final of a four-game series at Comerica Park. The Tigers are favored in this one, at -290, while the underdog Guardians have +234 odds to win. Detroit is a 1.5-run favorite (at -125 odds). The over/under is 7 runs for this contest.

Check out everything you need to know from a betting perspective on the Tigers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Detroit Tigers.

Tigers vs. Guardians Game Information & Odds

• When: Sunday, May 25, 2025 at 11:35 a.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: Roku

Tigers vs. Guardians Prediction

• Score Prediction: Tigers 4, Guardians 3
• Total Prediction: Under 7 runs
• Win Probabilities: Tigers 59%, Guardians 41%

Tigers vs. Guardians Betting Insights

• This season, the Tigers have won 22 out of the 32 games, or 68.8%, in which they've been favored.
• Detroit has played as favorites of -290 or more once this season and won that game.
• The sportsbooks' moneyline implies a 74.4% chance of a victory for the Tigers.
• The Guardians have won in 16, or 53.3%, of the 30 contests they have been named as odds-on underdogs this year.
• This will be the worst odds to win that sportsbooks have given Cleveland this season with a +234 moneyline set for this game.
• The moneyline set for this matchup implies the Guardians have a 29.9% chance of coming away with a victory in the contest.

Tigers Recent Betting Performance

• The Tigers played as the moneyline favorite for seven of their last 10 games, and finished 3-4 in those matchups.
• Over their last 10 matchups, the Tigers and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Tigers' ATS record is 2-8-0 over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Spencer Torkelson is the Tigers best power option, hitting 13 homers this season in addition to delivering 40 RBI, both team highs.
• Torkelson is 10th in home runs and seventh in RBI among all hitters in MLB.
• Gleyber Torres' .281 batting average paces his team.
• Torres is 123rd in homers and 69th in RBI among all MLB hitters this year.
• Greene has 10 doubles, 12 home runs and 16 walks while batting .274.
• Kerry Carpenter has a club-best .281 batting average.
• Carpenter takes a three-game streak with at least one hit into this one. During his last five outings he is hitting .250 with two doubles, a home run, two walks and an RBI.

Tigers Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in six of their past 10 games and won five of those contests.
• When it comes to hitting the over, the Guardians and their opponents are 2-8-0 in their last 10 games with a total.
• The Guardians have six wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez is hitting .308 with 10 doubles, a triple, nine home runs and 17 walks, while getting on base at a rate of .365.
• Ramirez's home run total puts him 36th in the majors, and he is 69th in RBI.
• Ramirez takes a hitting streak of 17 games into this matchup. In his last 10 games he is hitting .372 with two doubles, a triple, three home runs, two walks and eight RBIs.
• Kwan is batting .320 to lead the lineup.
• Kwan ranks 151st in homers and 141st in RBI among all batters in the majors.
• Carlos Santana leads the Guardians with 27 runs batted in.
• Kyle Manzardo has a team-leading 10 home runs and has driven in 27 runs.

Guardians Team Props

Guardians vs. Tigers Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Detroit Tigers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Tigers

Cleveland Guardians