Reds vs. Cardinals Prediction, Odds, Picks - April 28

The St. Louis Cardinals and Brendan Donovan hit the field against Austin Hays and the Cincinnati Reds on Monday at Great American Ball Park. The Reds are the favorite in this one, at -123, while the underdog Cardinals have +104 odds to upset. St. Louis is the run-line favorite (-1.5). The over/under is 9.5 runs for the matchup (with -106 odds on the over and -114 odds on the under).

Take a look at everything you need from a betting perspective on the Reds-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. Cardinals Game Information & Odds

• When: Monday, April 28, 2025 at 6:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: MLB Network, FDSOH, and FDSMW

Reds vs. Cardinals Prediction

• Score Prediction: Reds 5, Cardinals 4
• Total Prediction: Over 9.5 runs
• Win Probabilities: Reds 55%, Cardinals 45%

Reds vs. Cardinals Betting Insights

• This season, the Reds have won eight out of the 13 games, or 61.5%, in which they've been favored.
• Cincinnati has a record of 6-2 in games when oddsmakers favor them by at least -123 on the moneyline.
• The bookmakers' moneyline implies a 55.2% chance of a victory for the Reds.
• The Cardinals have been chosen as underdogs in 19 games this year and have walked away with the win eight times (42.1%) in those games.
• St. Louis has a mark of 3-9 in contests where bookmakers favor it by +104 or worse on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 49% chance of pulling out a win.

Reds Recent Betting Performance

• The Reds played as the moneyline favorite for seven of their last 10 games, and finished 4-3 in those matchups.
• In their last 10 outings -- all had a set run total -- the Reds and their opponents combined to go over the total six times.
• The Reds have gone 5-5-0 against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz has a team-high five home runs and 24 runs batted in.
• Of all batters in the majors, De La Cruz is 36th in homers and sixth in RBI.
• De La Cruz has collected a hit in 11 games in a row. In his last 10 outings he is hitting .341 with two home runs, six walks and six RBI.
• TJ Friedl is batting .294 with six doubles, a triple, a home run and nine walks.
• Friedl is 199th in home runs and 96th in RBI on the season.
• Friedl carries a two-game streak with at least one hit into this contest. During his last five outings he is hitting .292 with three doubles, a walk and two RBI.
• Hays has launched a team-high five home runs.
• Hays is on a three-game hitting streak entering this contest. During his last five outings he is hitting .353 with two doubles, two home runs, three walks and four RBI.
• Noelvi Marte has four doubles, three home runs and three walks while hitting .364.
• Marte is riding a three-game hitting streak into this one. In his last five games he is hitting .381 with a double, two home runs, two walks and eight RBI.

Reds Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in seven of their past 10 games and won one of those contests.
• The Cardinals and their opponents have combined to hit the over five times in their last 10 games with a total.
• The Cardinals are 3-7-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Lars Nootbaar paces the Cardinals in home runs (four) and runs batted in (17).
• Among all hitters in MLB, Nootbaar is 57th in home runs and 30th in RBI.
• Nootbaar has collected a hit in three straight games. During his last five outings he is batting .421 with a double, a home run, six walks and six RBI.
• Donovan is batting .359 to lead the lineup.
• Among all major league batters, Donovan ranks 99th in home runs and 36th in RBI.
• Nolan James Arenado is hitting .255 with eight doubles, three home runs and 14 walks.
• Victor Scott II is batting .264 with five doubles, a triple, a home run and eight walks.

Cardinals Team Props

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