Red Sox vs. Mariners Prediction, Odds, Picks - April 22

The Boston Red Sox and Trevor Story will take the field against the Seattle Mariners and Cal Raleigh on Tuesday at 6:45 p.m. ET in the first game of a three-game series at Fenway Park. The Red Sox are the favorite in this one, at -123, while the underdog Mariners have +103 odds to play spoiler. Boston is a 1.5-run favorite (at +157 odds). The total is 9.5 runs for the game.

Check out everything you need to know from a betting perspective on the Red Sox-Mariners game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Mariners vs. Blue Jays Highlights | MLB on FOX

Check out the best moments between the Seattle Mariners and Toronto Blue Jays

Red Sox vs. Mariners Game Information & Odds

• When: Tuesday, April 22, 2025 at 6:45 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: NESN and ROOT Sports NW

Red Sox vs. Mariners Prediction

• Score Prediction: Mariners 5, Red Sox 4
• Total Prediction: Under 9.5 runs
• Win Probabilities: Red Sox 55%, Mariners 45%

Red Sox vs. Mariners Betting Insights

• This season, the Red Sox have won 10 out of the 17 games, or 58.8%, in which they've been favored.
• Boston is 8-6 this season when entering a game favored by -123 or more on the moneyline.
• The implied probability of a win from the Red Sox, based on the moneyline, is 55.2%.
• The Mariners have won in four of the eight contests they have been named as odds-on underdogs this year.
• This season, Seattle has come away with a win four times in six chances when named as an underdog of at least +103 or longer on the moneyline.
• The Mariners have an implied victory probability of 49.3% according to the moneyline set by sportsbooks for this matchup.

Red Sox Recent Betting Performance

• The Red Sox have a 4-3 record over the seven games they were a moneyline favorite in their last 10 matchups.
• Over their last 10 outings (all had set totals), the Red Sox combined with their opponents to go over the total five times.
• The Red Sox's record against the spread is 5-5-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Alexander David Bregman leads the Red Sox with 16 runs batted in.
• Bregman ranks 43rd in home runs and 20th in RBI among all hitters in the majors.
• Bregman carries a two-game hitting streak into this matchup. During his last five outings he is hitting .389 with a double, two home runs, five walks and four RBI.
• Wilyer Abreu has five doubles, four home runs and 15 walks while batting .274.
• Abreu ranks 43rd in home runs and 25th in RBI among all hitters in the majors.
• Story has accumulated a team-best batting average of .337, and paces the Red Sox in home runs (five).
• Story will look to build on his three-game hitting in this matchup. During his last five outings he is hitting .450 with two home runs, a walk and seven RBI.
• Kristian Campbell has five doubles, three home runs and 14 walks while hitting .316.
• Campbell brings a three-game streak with at least one hit into this one. During his last five outings he is hitting .278 with a double, four walks and two RBI.

Red Sox Team Props

Mariners Recent Betting Performance

• The Mariners have played as underdogs in four of their past 10 games and have gone 3-1 in those contests.
• In their last 10 games with a total, the Mariners and their opponents have combined to hit the over seven times.
• The Mariners have a record of 8-2-0 ATS over their last 10 games.

Mariners Recent Stats

Mariners Player Insights

• Raleigh paces the Mariners with nine homers while posting a team-leading batting average of .244.
• In all of the big leagues, Raleigh is first in homers and 20th in RBI.
• Raleigh brings a hitting streak of five games into this matchup. In his last five games he is batting .364 with a double, four home runs, four walks and eight RBI.
• Randy Arozarena has driven in the most runs for the Mariners with 17 runs batted in.
• Arozarena ranks 43rd in homers and 14th in RBI among all major league hitters this year.
• Dylan Moore has a double, five home runs and five walks while hitting .316.
• Julio Rodriguez is hitting .188 with two doubles, two triples, three home runs and 12 walks.

Mariners Team Props

White Sox vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Boston Red Sox

Seattle Mariners