Padres vs. Rockies Prediction, Odds, Picks - September 12

Luis Arraez and the San Diego Padres hit the field against Mickey Moniak and the Colorado Rockies on Friday at 9:40 p.m. ET, in the second of a four-game series at PETCO Park. The Padres are the favorite in this one, at -273, while the underdog Rockies have +221 odds to play spoiler. San Diego (-1.5) is the favorite on the run line. The total is 8.5 runs for this game.

Check out everything you need to know from a betting perspective on the Padres-Rockies game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Reds vs. Padres Highlights | MLB on FOX

Enjoy the best moments between Cincinnati Reds and the San Diego Padres.

Padres vs. Rockies Game Information & Odds

• When: Friday, September 12, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and COLR

Padres vs. Rockies Prediction

• Score Prediction: Padres 6, Rockies 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Padres 62%, Rockies 38%

Padres vs. Rockies Betting Insights

• This season, the Padres have won 48 out of the 82 games, or 58.5%, in which they've been favored.
• San Diego has played as favorites of -273 or more once this season and lost that game.
• The implied probability of a win from the Padres, based on the moneyline, is 73.2%.
• The Rockies have won in 39, or 27.3%, of the 143 contests they have been named as odds-on underdogs this year.
• This season, Colorado has come away with a win 10 times in 49 chances when named as an underdog of at least +221 or longer on the moneyline.
• The Rockies have an implied victory probability of 31.2% according to the moneyline set for this matchup.

Padres Recent Betting Performance

• The Padres have a 4-6 record from the 10 games they were favored on the moneyline over their last 10 matchups.
• In their last 10 outings (all had set totals), the Padres combined with their opponents to hit the over on the total two times.
• The Padres' ATS record is 3-7-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. is hitting .260 with 27 doubles, two triples, 21 home runs and 84 walks.
• Among all MLB hitters, Tatis ranks 73rd in batting average, 19th in on-base percentage, and 77th in slugging.
• Manny Machado has shown his power as he leads his team with 23 home runs and 84 runs batted in.
• Machado ranks 49th in home runs and 25th in RBI among all hitters in MLB.
• Arraez leads the Padres with a team-high batting average of .285.
• Arraez will look to build on his two-game hitting in this game. In his last five games he is hitting .235 with two walks and an RBI.
• Ramon Laureano has hit 23 home runs to pace his team.

Padres Team Props

Rockies Recent Betting Performance

• The Rockies have played as underdogs in 10 of their past 10 games and won one of those contests.
• When it comes to hitting the over, the Rockies and their opponents are 4-5-1 in their last 10 games with a total.
• The Rockies have one win against the spread in their last 10 chances.

Rockies Recent Stats

Rockies Player Insights

• Hunter Goodman paces the Rockies in home runs (30), runs batted in (87) and has posted a team-best batting average of .280.
• Goodman ranks 13th in homers and 23rd in RBI among all hitters in the majors.
• Moniak is hitting .262 with 17 doubles, eight triples, 19 home runs and 21 walks.
• Moniak ranks 76th in homers and 113th in RBI among all MLB hitters this year.
• Jordan Beck is batting .267 with 26 doubles, five triples, 15 home runs and 41 walks.
• Brenton Doyle has 21 doubles, two triples, 14 home runs and 29 walks while hitting .243.

Rockies Team Props

Padres vs. Rockies Highlights | MLB on FOX

Check out the best highlights between the San Diego Padres and Colorado Rockies.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Diego Padres

Colorado Rockies