Padres vs. Orioles Prediction, Odds, Picks - September 1

Fernando Tatis Jr. and Gunnar Henderson will be among the star attractions when the San Diego Padres play the Baltimore Orioles on Monday at 6:40 p.m. ET, at PETCO Park. Oddsmakers list the Padres as -170 moneyline favorites, while giving the underdog Orioles +142 moneyline odds to win. San Diego is a 1.5-run favorite (at +132 odds). The over/under for the matchup is set at 7.5 runs.

Here is everything you need to know from a betting perspective on the Padres-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Twins Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and Minnesota Twins.

Padres vs. Orioles Game Information & Odds

• When: Monday, September 1, 2025 at 6:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and MASN2

Padres vs. Orioles Prediction

• Score Prediction: Padres 5, Orioles 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Padres 56%, Orioles 44%

Padres vs. Orioles Betting Insights

• This season, the Padres have been favored 72 times and won 44, or 61.1%, of those games.
• San Diego has entered 20 games this season favored by -170 or more and is 13-7 in those contests.
• The moneyline for this contest implies a 63% chance of a victory for the Padres.
• The Orioles have won in 32, or 43.2%, of the 74 contests they have been named as odds-on underdogs this year.
• This season, Baltimore has been victorious five times in 14 chances when named as an underdog of at least +142 or longer on the moneyline.
• The Orioles have an implied victory probability of 41.3% according to the moneyline set for this matchup.

Padres Recent Betting Performance

• The Padres were the moneyline favorite for three of their last 10 games, and they finished 2-1 in those matchups.
• In their last 10 outings -- all had a set run total -- the Padres and their opponents combined to hit the over on the total seven times.
• The Padres' ATS record is 5-5-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis has 27 doubles, two triples, 18 home runs and 81 walks while batting .264.
• Of all hitters in MLB, Tatis' home run total ranks him 75th, and his RBI tally puts him 99th.
• Manny Machado has 79 RBI while batting .286. Both lead his team.
• Machado ranks 53rd in homers and 25th in RBI among all MLB hitters this year.
• Luis Arraez is hitting .282 with 29 doubles, four triples, six home runs and 27 walks.
• Arraez is on a three-game hitting streak entering this contest. During his last five outings he is hitting .167 with a walk and an RBI.
• Ramon Laureano's 22 home runs pace his team.
• Laureano brings a two-game streak with at least one hit into this one. During his last five outings he is batting .238 with a double, two home runs and seven RBIs.

Padres Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in seven of their past 10 games and lost each of those contests.
• In their last 10 games with a total, the Orioles and their opponents have combined to hit the over five times.
• The Orioles have four wins against the spread in their last 10 chances.

Orioles Recent Stats

Orioles Player Insights

• Henderson leads the Orioles with 16 home runs and 61 runs batted in, while posting a team-high batting average of .280.
• Henderson's home run total places him 97th in MLB, and he ranks 83rd in RBI.
• Henderson has collected a hit in three straight games. In his last five games he is hitting .250 with two RBIs.
• Jackson Holliday is hitting .246 with 19 doubles, three triples, 15 home runs and 44 walks.
• Among all MLB hitters, Holliday ranks 112th in homers and 131st in RBI.
• Ryan Mountcastle is hitting .264 with 17 doubles, five home runs and 12 walks.
• Colton Cowser is hitting .211 with 12 doubles, 12 home runs and 17 walks.

Orioles Team Props

Padres vs. Twins Highlights | MLB on FOX

Check out the best moments between the San Diego Padres and Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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