Padres vs. Guardians Prediction, Odds, Picks - April 2

Jackson Merrill and Jose Ramirez will be among the stars on display when the San Diego Padres play the Cleveland Guardians on Wednesday at 4:10 p.m. ET, at PETCO Park. The Padres are -175 moneyline favorites for this matchup against the Guardians (+147). San Diego is a 1.5-run favorite (at +125 odds). The total for the game is listed at 7.5 runs.

Here is everything you need to know from a betting perspective on the Padres-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Guardians Game Information & Odds

• When: Wednesday, April 2, 2025 at 4:10 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and CLEG

Padres vs. Guardians Prediction

• Score Prediction: Padres 5, Guardians 2
• Total Prediction: Under 7.5 runs
• Win Probabilities: Padres 75%, Guardians 25%

Padres vs. Guardians Betting Insights

• The Padres finished with a 64-42 record in games they were favored on the moneyline last season (winning 60.4% of those games).
• San Diego had a record of 20-10 in games it played as a moneyline favorite with odds of -175 or shorter last year (66.7%).
• The Padres have an implied moneyline win probability of 63.6% in this game.
• The Guardians won 29, or 44.6%, of the 65 games they played as underdogs last season.

Padres Player Insights

• Fernando Tatis Jr. leads the Padres with one home runs while putting up a team-best batting average of .409.
• Tatis ranks 45th in homers and 21st in RBI among all hitters in the majors.
• Manny Machado has three doubles and two walks while batting .381.
• Machado ranks 132nd in homers and 101st in RBI in the major leagues.
• Merrill has racked up a team-best one home runs and six runs batted in.
• Gavin Sheets has hit one home runs to pace his team.

Padres Team Props

Guardians Player Insights

• Ramirez had 39 home runs and 118 runs batted in last season.
• Steven Kwan had a .292 batting average with 140 hits.
• Carlos Santana hit .238 last season with 26 doubles, 23 home runs and 65 walks.
• Lane Thomas hit .237 with 26 doubles, three triples, 15 home runs and 44 walks.

Guardians Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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