Padres vs. Giants Prediction, Odds, Picks - June 5

Gavin Sheets and the San Diego Padres take the field on Thursday at Oracle Park against Robbie Ray, who is starting for the San Francisco Giants. First pitch will be at 3:45 p.m. ET for the final game of a four-game series. The favored Padres have -115 moneyline odds against the underdog Giants, who are listed at -104. San Diego is favored on the run line (-1.5). The total is 7 runs for this game (with -117 odds on the over and -103 odds to go under).

Here's everything you need to know from a betting perspective on the Padres-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Giants Game Information & Odds

• When: Thursday, June 5, 2025 at 3:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and SDPA

Padres vs. Giants Prediction

• Score Prediction: Giants 4, Padres 3
• Total Prediction: Under 7 runs
• Win Probabilities: Padres 56%, Giants 44%

Padres vs. Giants Betting Insights

• The Padres have entered the game as favorites 35 times this season and won 21, or 60%, of those games.
• This season San Diego has won 20 of its 33 games, or 60.6%, when favored by at least -115 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Padres have a 53.5% chance to win.
• The Giants have been chosen as underdogs in 24 games this year and have walked away with the win 12 times (50%) in those games.
• This year, San Francisco has won nine of 18 games when listed as at least -104 or worse on the moneyline.
• The Giants have an implied victory probability of 51% according to the moneyline set for this matchup.

Padres Recent Betting Performance

• The Padres went 4-3 across the seven games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups (all 10 of them had set totals), the Padres and their opponents combined to go over the run total four times.
• The Padres' ATS record is 5-5-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. leads the Padres with 13 home runs on the year. He's also hitting .273 with 28 RBI.
• Of all hitters in the majors, Tatis ranks 16th in home runs and 80th in RBI.
• Tatis carries a three-game hitting streak into this matchup. In his last five games he is hitting .316 with a double and three walks.
• Manny Machado is hitting .314 to pace his team.
• Machado is 92nd in homers and 74th in RBI in the bigs.
• Machado heads into this game looking for his third game in a row with a hit. During his last five outings he is batting .316 with a home run, two walks and four RBIs.
• Luis Arraez is hitting .281 with 12 doubles, three triples, three home runs and 11 walks.
• Sheets' 38 runs batted in lead his team.

Padres Team Props

Giants Recent Betting Performance

• In three games as underdogs over the last 10 matchups, the Giants have a record of 1-2.
• In their last 10 games with a total, the Giants and their opponents have failed to hit the over nine times.
• The Giants have a record of 3-7-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee has 16 doubles, two triples, six home runs and 15 walks while hitting .274.
• In all of MLB, Lee is 116th in homers and 54th in RBI.
• Heliot Ramos has showcased his ability as a power hitter this season, as he paces his team with 11 home runs with a club-high .292 batting average.
• Among all major league hitters, Ramos ranks 33rd in home runs and 45th in RBI.
• Wilmer Flores has collected a team-high 47 runs batted in.
• Matt Chapman leads the Giants with 11 home runs.

Giants Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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