Orioles vs. Twins Prediction, Odds, Picks - May 15

Gunnar Henderson and the Baltimore Orioles will try to defeat Byron Buxton and the Minnesota Twins at Oriole Park at Camden Yards on Thursday at 12:35 p.m. ET. The Orioles are -130 moneyline favorites in this matchup against the Twins (+110). Baltimore is a 1.5-run favorite (at +152 odds). A 9-run total has been set for the contest.

Check out everything you need from a betting perspective on the Orioles-Twins game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Orioles Game 2 Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and Baltimore Orioles Game 2.

Orioles vs. Twins Game Information & Odds

• When: Thursday, May 15, 2025 at 12:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MLB Network, MASN2, and MNNT

Orioles vs. Twins Prediction

• Score Prediction: Twins 4, Orioles 3
• Total Prediction: Under 9 runs
• Win Probabilities: Orioles 54%, Twins 46%

Orioles vs. Twins Betting Insights

• The Orioles have entered the game as favorites 24 times this season and won nine, or 37.5%, of those games.
• Baltimore has entered 14 games this season favored by -130 or more and is 5-9 in those contests.
• The implied probability of a win from the Orioles, based on the moneyline, is 56.5%.
• The Twins have been underdogs in 16 games this season and have come away with the win eight times (50%) in those contests.
• This season, Minnesota has come away with a win two times in five chances when named as an underdog of at least +110 or worse on the moneyline.
• The moneyline set for this matchup implies the Twins have a 47.6% chance of walking away with the win.

Orioles Recent Betting Performance

• The Orioles have a 2-5 record from the seven games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings (all had set totals), the Orioles combined with their opponents to hit the over on the run total five times.
• The Orioles are 2-8-0 against the spread over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins is the Orioles best power hitter, connecting on eight round-trippers this season in addition to accumulating 25 RBI, both team highs.
• Among all hitters in baseball, Mullins' home run total places him 33rd, and his RBI tally ranks him 36th.
• Ryan O'Hearn is hitting .287 with four doubles, seven home runs and 13 walks.
• Henderson leads the Orioles with a .275 batting average.
• Henderson is on a seven-game hitting streak entering this contest. In his last 10 games he is batting .381 with two doubles, a triple, three home runs, four walks and seven RBIs.
• Adley Rutschman is hitting .197 with four doubles, a triple, four home runs and 19 walks.

Orioles Team Props

Twins Recent Betting Performance

• The Twins have played as underdogs in six of their past 10 games and won each of those contests.
• In their last 10 games with a total, the Twins and their opponents have combined to hit the over five times.
• The Twins have a record of 9-1-0 ATS over their last 10 games.

Twins Recent Stats

Twins Player Insights

• Buxton leads the Twins with nine home runs and 26 runs batted in, while recording a team-high batting average of .258.
• Among all hitters in the majors, Buxton ranks 23rd in homers and 29th in RBI.
• Trevor Larnach is hitting .250 with five doubles, seven home runs and 17 walks.
• Larnach is currently 46th in home runs and 55th in RBI in the major leagues.
• Ty France is hitting .255 with eight doubles, three home runs and 10 walks.
• Harrison Bader is batting .300 with six doubles, four home runs and 12 walks.

Twins Team Props

Twins vs. Orioles Game 2 Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and Baltimore Orioles Game 2.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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