Orioles vs. Rays Prediction, Odds, Picks - September 24

Gunnar Henderson and Chandler Simpson will look to continue their recent offensive production when the Baltimore Orioles and Tampa Bay Rays play at Oriole Park at Camden Yards on Wednesday, at 6:35 p.m. ET. Bookmakers list the Orioles as -123 favorites on the moneyline, while giving the underdog Rays +104 moneyline odds to win. Baltimore is the favorite on the run line (-1.5 with +167 odds). An 8-run over/under is listed for this game.

Here's everything you need to know from a betting perspective on the Orioles-Rays game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best highlights between the Boston Red Sox and the Tampa Bay Rays.

Orioles vs. Rays Game Information & Odds

• When: Wednesday, September 24, 2025 at 6:35 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: Fox Sports 1, MASN2, and FDSSUN

Orioles vs. Rays Prediction

• Score Prediction: Orioles 4, Rays 3
• Total Prediction: Under 8 runs
• Win Probabilities: Orioles 50%, Rays 50%

Orioles vs. Rays Betting Insights

• This season, the Orioles have been favored 66 times and won 33, or 50%, of those games.
• Baltimore has entered 45 games this season favored by -123 or more and is 24-21 in those contests.
• Bookmakers have implied with the moneyline set for this matchup that the Orioles have a 55.2% chance to win.
• The Rays have been victorious in 32, or 41.6%, of the 77 contests they have been chosen as underdogs in this season.
• This season, Tampa Bay has been victorious 23 times in 49 chances when named as an underdog of at least +104 or longer on the moneyline.
• The Rays have an implied victory probability of 49% according to the moneyline set for this matchup.

Orioles Recent Betting Performance

• In the last 10 games, the Orioles have been listed as the moneyline favorite by oddsmakers only twice, and they won both games.
• Over their last 10 outings (all had set totals), the Orioles combined with their opponents to hit the over on the run total three times.
• The Orioles' ATS record is 5-5-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Henderson has racked up a team-best batting average of .274 and leads the Orioles in runs batted in (67).
• Of all hitters in MLB, Henderson is 123rd in home runs and 93rd in RBI.
• Jackson Holliday's 17 home runs pace his team.
• Holliday ranks 110th in home runs and 140th in RBI in the bigs.
• Jordan Westburg is hitting .264 with 10 doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman is hitting .224 with 16 doubles, a triple, nine home runs and 37 walks.

Orioles Team Props

Rays Recent Betting Performance

• In six games as underdogs over the last 10 matchups, the Rays have a record of 3-3.
• In their last 10 games with a total, the Rays and their opponents have combined to hit the over five times.
• The Rays have six wins against the spread in their last 10 chances.

Rays Recent Stats

Rays Player Insights

• Junior Caminero paces the Rays in home runs (44) and runs batted in (108).
• Among all batters in MLB, Caminero ranks sixth in homers and sixth in RBI.
• Yandy Diaz is batting .301 to lead the lineup.
• Diaz ranks 45th among all hitters in the big leagues in home runs, and 37th in RBI.
• Brandon Lowe has 18 doubles, 30 home runs and 37 walks while hitting .257.
• Simpson is hitting .298 with 14 doubles, three triples and 20 walks.

Rays Team Props

Red Sox vs. Rays Highlights | MLB on FOX

Check out the best highlights between the Boston Red Sox and the Tampa Bay Rays.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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