Mariners vs. White Sox Prediction, Odds, Picks - May 21

Julio Rodriguez and the Seattle Mariners will play Miguel Vargas and the Chicago White Sox at Rate Field in the final of a three-game series, Wednesday at 2:10 p.m. ET. The Mariners are -149 moneyline favorites in this matchup against the White Sox (+126). Seattle is favored on the run line (-1.5 with +112 odds). The contest's total has been set at 8.5 runs.

Here's everything you need from a betting perspective on the Mariners-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Mariners vs. White Sox Game Information & Odds

• When: Wednesday, May 21, 2025 at 2:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and ROOT Sports NW

Mariners vs. White Sox Prediction

• Score Prediction: Mariners 5, White Sox 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Mariners 52%, White Sox 48%

Mariners vs. White Sox Betting Insights

• The Mariners have been favorites in 28 games this season and won 16 (57.1%) of those contests.
• Seattle is 6-5 this season when entering a game favored by -149 or more on the moneyline.
• The implied probability of a win from the Mariners, based on the moneyline, is 59.8%.
• The White Sox have been victorious in 15, or 30.6%, of the 49 contests they have been chosen as underdogs in this season.
• Chicago has a mark of 13-31 in contests where oddsmakers favor it by +126 or worse on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 44.2% chance of coming away with a victory in the contest.

Mariners Recent Betting Performance

• The Mariners were favored on the moneyline for four of their last 10 games, and they went 1-3 in those matchups.
• In their last 10 outings -- all had a set run total -- the Mariners and their opponents combined to hit the over on the total three times.
• The Mariners' ATS record is 6-4-0 over their past 10 games.

Mariners Recent Stats

Mariners Player Insights

• The Mariners' best power option comes in the form of Cal Raleigh and his 15-home-run 32-RBI season, both team highs.
• Among all hitters in the majors, Raleigh is fourth in home runs and 19th in RBI.
• Rodriguez has five doubles, two triples, eight home runs and 18 walks while hitting .232.
• Rodriguez ranks 41st in homers and 58th in RBI among all MLB hitters this season.
• Jorge Polanco has six doubles, 10 home runs and eight walks while batting .306.
• J.P. Crawford has a club-high .274 batting average.
• Crawford has recorded at least one hit in three games in a row. During his last five outings he is hitting .294 with a double, a home run, six walks and an RBI.

Mariners Team Props

White Sox Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 4-6.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over two times.
• The White Sox are 4-6-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas has posted a team-leading six home runs and has driven in 21 runs.
• In all of the majors, Vargas is 81st in homers and 96th in RBI.
• Luis Robert is hitting .182 with four doubles, five home runs and 21 walks.
• Among all major league hitters, Robert is 117th in home runs and 144th in RBI.
• Chase Meidroth is batting .295 with three doubles, a home run and 12 walks.
• Lenyn Sosa paces the White Sox with a .272 batting average.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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