Mariners vs. White Sox Prediction, Odds, Picks - May 20

Adrian Houser gets the nod for the Chicago White Sox on Tuesday at Rate Field against Julio Rodriguez and the Seattle Mariners. First pitch is at 7:40 p.m. ET for the second game of a three-game series. The White Sox are +152 moneyline underdogs in this matchup against the favorite Mariners (-182). Seattle is a 1.5-run favorite (at -110 odds). The contest's over/under has been listed at 8.5 runs.

Here is everything you need from a betting perspective on the Mariners-White Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Mariners vs. White Sox Highlights | MLB on FOX

Check out the top moments from this MLB game between the Seattle Mariners and the Chicago White Sox!

Mariners vs. White Sox Game Information & Odds

• When: Tuesday, May 20, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and ROOT Sports NW

Mariners vs. White Sox Prediction

• Score Prediction: Mariners 5, White Sox 4
• Total Prediction: Under 8.5 runs
• Win Probabilities: Mariners 56%, White Sox 44%

Mariners vs. White Sox Betting Insights

• This season, the Mariners have won 16 out of the 27 games, or 59.3%, in which they've been favored.
• Seattle is 4-2 this season when entering a game favored by -182 or more on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Mariners have a 64.5% chance to win.
• The White Sox have been underdogs in 48 games this season and have come away with the win 14 times (29.2%) in those contests.
• This year, Chicago has won seven of 31 games when listed as at least +152 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the White Sox have a 39.7% chance of pulling out a win.

Mariners Recent Betting Performance

• The Mariners have a 1-3 record from the four games they were favored on the moneyline over their last 10 matchups.
• In their last 10 outings (all had set totals), the Mariners combined with their opponents to go over the total four times.
• The Mariners have a 6-4-0 record against the spread over their past 10 games.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh paces the Mariners with 15 home runs and 32 runs batted in.
• Among all hitters in MLB, Raleigh's home run total ranks him third, and his RBI tally puts him 17th.
• Rodriguez has five doubles, two triples, eight home runs and 17 walks while hitting .235.
• Rodriguez is 40th in home runs and 50th in RBI among all hitters in MLB.
• Rodriguez carries a seven-game streak with at least one hit into this contest. During his last 10 outings he is hitting .262 with a double, two home runs and eight RBIs.
• Jorge Polanco has six doubles, 10 home runs and eight walks while hitting .314.
• Randy Arozarena has 10 doubles, six home runs and 27 walks while batting .236.

Mariners Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won four of those contests.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over two times.
• The White Sox are 4-6-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas has posted a team-high six home runs and has driven in 21 runs.
• Among all hitters in MLB, Vargas' home run total ranks 80th and his RBI tally ranks 92nd.
• Luis Robert is hitting .186 with four doubles, five home runs and 21 walks.
• Robert ranks 113th among all batters in the majors in home runs, and 140th in RBI.
• Chase Meidroth is batting .286 with three doubles, a home run and 12 walks.
• Lenyn Sosa leads the team in batting average with a mark of .265.

White Sox Team Props

Mariners vs. White Sox Highlights | MLB on FOX

Check out the top moments from this MLB game between the Seattle Mariners and the Chicago White Sox!

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Chicago White Sox

Seattle Mariners