Guardians vs. Tigers Prediction, Odds, Picks - September 24

Jack Flaherty takes the mound for the Detroit Tigers on Wednesday at Progressive Field against Jose Ramirez and the Cleveland Guardians. First pitch is at 6:40 p.m. ET. Oddsmakers list the Guardians as -149 moneyline favorites, while giving the underdog Tigers +126 moneyline odds to win. Cleveland is favored on the run line (-1.5 with +148 odds). The over/under is 7.5 runs for this game.

Check out everything you need to know from a betting perspective on the Guardians-Tigers game, regarding the run line, moneyline and total, plus expert picks.

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Tigers vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between the Detroit Tigers and the Cleveland Guardians.

Guardians vs. Tigers Game Information & Odds

• When: Wednesday, September 24, 2025 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and FDSDET

Guardians vs. Tigers Prediction

• Score Prediction: Guardians 5, Tigers 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Guardians 52%, Tigers 48%

Guardians vs. Tigers Betting Insights

• The Guardians have entered the game as favorites 67 times this season and won 42, or 62.7%, of those games.
• Cleveland has entered 15 games this season favored by -149 or more and is 11-4 in those contests.
• The sportsbooks' moneyline implies a 59.8% chance of a victory for the Guardians.
• The Tigers have won in 22, or 47.8%, of the 46 contests they have been named as odds-on underdogs this year.
• This season, Detroit has been victorious six times in 14 chances when named as an underdog of at least +126 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Tigers have a 44.2% chance of pulling out a win.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite in five of their last 10 games, and they went 4-1 in those matchups.
• Over their last 10 outings, the Guardians and their opponents combined to go over the total two times (all 10 games had set totals).
• The Guardians' ATS record is 8-2-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez has racked up a team-best batting average of .282, while leading the Guardians in home runs (30) and runs batted in (82).
• Among all batters in the majors, Ramirez ranks 21st in homers and 42nd in RBI.
• Ramirez takes a hitting streak of six games into this game. During his last 10 outings he is hitting .278 with two doubles, two home runs, seven walks and five RBIs.
• Steven Kwan is hitting .277 with 29 doubles, a triple, 11 home runs and 54 walks.
• Among all major league hitters, Kwan ranks 186th in homers and 140th in RBI.
• Kwan carries a five-game streak with at least one hit into this contest. During his last five outings he is hitting .409 with two doubles, a home run, a walk and six RBIs.
• Kyle Manzardo is hitting .236 with 18 doubles, two triples, 26 home runs and 48 walks.
• Manzardo is on a three-game hitting streak entering this contest. In his last five games he is batting .158 with a double, a walk and an RBI.
• Angel Martinez is batting .228 with 23 doubles, two triples, 11 home runs and 22 walks.

Guardians Team Props

Tigers Recent Betting Performance

• The Tigers are not favored for the first time in a while, as they have not been underdogs in their last 10 games.
• In their last 10 games with a total, the Tigers and their opponents are 6-4-0 when it comes to hitting the over.
• The Tigers are 1-9-0 ATS over their last 10 games.

Tigers Recent Stats

Tigers Player Insights

• Gleyber Torres has 22 doubles, 16 home runs and 85 walks while batting .259.
• Torres is 123rd in homers and 66th in RBI among all batters in the majors.
• Riley Greene proven to be a run producer as he paces his team with 35 home runs and 110 RBI, with a team-high .261 batting average.
• Greene is 10th overall in home runs and fifth in RBI this year.
• Spencer Torkelson has 27 doubles, a triple, 31 home runs and 70 walks while hitting .241.
• Zach McKinstry has 23 doubles, 11 triples, 12 home runs and 46 walks while hitting .260.

Tigers Team Props

Tigers vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between the Detroit Tigers and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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