Guardians vs. Nationals Prediction, Odds, Picks - May 6

Steven Kwan and Nathaniel Lowe will be among the star attractions when the Cleveland Guardians face the Washington Nationals on Tuesday at 3:35 p.m. ET, at Nationals Park. The Guardians are the favorite in this one, at -118, while the underdog Nationals have -101 odds to play spoiler. Cleveland is favored on the run line (-1.5 with +137 odds). The total is 9.5 runs for this game.

Here is everything you need to know from a betting perspective on the Guardians-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Blue Jays Highlights | MLB on FOX

Check out the best moments from the Cleveland Guardians vs. Toronto Blue Jays on Sunday, May 4th.

Guardians vs. Nationals Game Information & Odds

• When: Tuesday, May 6, 2025 at 3:35 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN2 and CLEG

Guardians vs. Nationals Prediction

• Score Prediction: Nationals 6, Guardians 5
• Total Prediction: Over 9.5 runs
• Win Probabilities: Guardians 52%, Nationals 48%

Guardians vs. Nationals Betting Insights

• This season, the Guardians have been favored 13 times and won 10, or 76.9%, of those games.
• Cleveland has a record of 8-2, a 80% win rate, when favored by -118 or more by bookmakers this season.
• The sportsbooks' moneyline implies a 54.1% chance of a victory for the Guardians.
• The Nationals have been underdogs in 29 games this season and have come away with the win 14 times (48.3%) in those contests.
• This year, Washington has won 12 of 26 games when listed as at least -101 or worse on the moneyline.
• The Nationals have an implied victory probability of 50.2% according to the moneyline set by sportsbooks for this matchup.

Guardians Recent Betting Performance

• The Guardians went 2-1 over the three games they were moneyline favorites in their last 10 matchups.
• Over their last 10 outings -- all had a set run total -- the Guardians and their opponents combined to hit the over on the total six times.
• The Guardians' record against the spread is 4-6-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• The Guardians best hitter so far this season is Kwan, who's hitting at a team-leading .333 rate along with four homers and 16 RBI.
• Among all MLB hitters, Kwan is sixth in batting average, 24th in on-base percentage, and 45th in slugging.
• Kwan takes a hitting streak of three games into this game. During his last five outings he is hitting .333 with a double, two walks and an RBI.
• Jose Ramirez is batting .265 with five doubles, five home runs and 10 walks.
• Of all MLB hitters, Ramirez is 59th in homers and 88th in RBI.
• Kyle Manzardo leads the Guardians in home runs (eight) and runs batted in (20).
• Carlos Santana has two doubles, three home runs and 15 walks while hitting .219.

Guardians Team Props

Nationals Recent Betting Performance

• The Nationals have played as underdogs in 10 of their past 10 games and won five of those contests.
• When it comes to hitting the over, the Nationals and their opponents are 5-5-0 in their last 10 games with a total.
• The Nationals have won six of their last 10 games against the spread.

Nationals Recent Stats

Nationals Player Insights

• James Wood paces the Nationals with nine home runs.
• Among all batters in MLB, Wood's home run total is seventh and his RBI tally is 32nd.
• Wood brings a hitting streak of four games into this matchup. During his last five outings he is batting .368 with two doubles and four walks.
• Lowe has put up 27 runs batted in to lead his team.
• Lowe is 44th overall in home runs and eighth in RBI this season.
• Luis Garcia is hitting .234 with five doubles, three home runs and eight walks.
• C.J. Abrams is batting .284 with five doubles, two triples, four home runs and four walks.

Nationals Team Props

Guardians vs. Blue Jays Highlights | MLB on FOX

Check out the best moments from the Cleveland Guardians vs. Toronto Blue Jays on Sunday, May 4th.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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