Guardians vs. Angels Prediction, Odds, Picks - April 4

Taylor Ward and the Los Angeles Angels play the Cleveland Guardians on Friday at Angel Stadium. Gavin Williams will be on the mound for Cleveland, with first pitch at 9:38 p.m. ET. Oddsmakers list the Guardians as -116 favorites on the moneyline, while giving the underdog Angels -104 moneyline odds to win. Cleveland is a 1.5-run favorite (at +145 odds). The total is 8 runs for the game (with -105 odds on the over and -115 odds on the under).

Here's everything you need from a betting perspective on the Guardians-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Angels Game Information & Odds

• When: Friday, April 4, 2025 at 9:38 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and CLEG

Guardians vs. Angels Prediction

• Score Prediction: Guardians 4, Angels 0
• Total Prediction: Under 8 runs
• Win Probabilities: Guardians 92%, Angels 8%

Guardians vs. Angels Betting Insights

• This is the first time the Guardians will play as favorites this season.
• Cleveland has not entered a game this season as bigger favorites on the moneyline than the -116 odds on them winning this game.
• The oddsmakers' moneyline implies a 53.7% chance of a victory for the Guardians.
• The Angels have been underdogs in three games this season and have come away with the win two times (66.7%) in those contests.
• This season, Los Angeles has been victorious two times in three chances when named as an underdog of at least -104 or longer on the moneyline.
• The Angels have an implied victory probability of 51% according to the moneyline set for this matchup.

Guardians Player Insights

• The Guardians' best power option comes in the form of Kyle Manzardo and his two-dinger seven-RBI season, both team highs.
• Including all MLB hitters, Manzardo ranks 87th in batting average, 77th in on-base percentage, and 19th in slugging.
• Steven Kwan is hitting .348 to lead his team.
• Kwan ranks 59th in home runs and 86th in RBI in the bigs.
• Kwan enters this game looking for his third game in a row with a hit. In his last five games he is hitting .316 with a home run, two walks and two RBI.
• Carlos Santana has two doubles and two walks while hitting .261.
• Jose Ramirez is hitting .294 with two doubles, a home run and a walk.

Guardians Team Props

Angels Player Insights

• Kyren Paris is hitting .444 with a triple, a home run and two walks.
• In all of the majors, Paris ranks 59th in homers and 86th in RBI.
• Paris has collected a hit in four straight games. During his last five outings he is batting .444 with a triple, a home run, two walks and three RBI.
• Nolan Schanuel's .292 batting average is a team-high mark.
• Schanuel ranks 154th among all hitters in MLB in home runs, and 86th in RBI.
• Mike Trout has a team-best five runs batted in.
• Logan O'Hoppe leads the Angels in home runs (two) and runs batted in (five).

Angels Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Angels

Cleveland Guardians