Giants vs. Astros Prediction, Odds, Picks - April 2

The San Francisco Giants and Houston Astros will play on Wednesday at Daikin Park, at 4:10 p.m. ET, with Matt Chapman and Yordan Alvarez among those expected to step up at the plate. The favored Giants have -137 moneyline odds to win against the underdog Astros, who are listed at +116. San Francisco is favored on the run line (-1.5). An 8-run total has been set in the game.

Here's everything you need from a betting perspective on the Giants-Astros game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Giants vs. Astros Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Houston Astros.

Giants vs. Astros Game Information & Odds

• When: Wednesday, April 2, 2025 at 4:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and NBCS-BA

Giants vs. Astros Prediction

• Score Prediction: Giants 3, Astros 1
• Total Prediction: Under 8 runs
• Win Probabilities: Giants 69%, Astros 31%

Giants vs. Astros Betting Insights

• The Giants won 57.5% of the games last season they were the moneyline favorite (46-34).
• San Francisco had a record of 26-13 in games it played as a moneyline favorite with odds of -137 or shorter last year (66.7%).
• Based on this contest's moneyline, the Giants' implied win probability is 57.8%.
• The Astros were underdogs 44 times last season and won 21, or 47.7%, of those games.

Giants Player Insights

• Willy Adames slugged 32 home runs and collected 112 RBI last season while batting .251.
• Chapman hit .247 with an OBP of .328 and a slugging percentage of .463.
• Heliot Ramos finished last season with a .269 batting average while adding 22 home runs and 72 RBI.
• Mike Yastrzemski collected 99 hits, posted an OBP of .302 and a .437 SLG.

Giants Team Props

Astros Player Insights

• Alvarez racked up a batting average of .308, with 35 home runs and 86 runs batted in last season.
• Jose Altuve had 31 doubles, 20 home runs and 47 walks while hitting .295.
• Yainer Diaz hit .299 last season with 29 doubles, three triples, 16 home runs and 24 walks.
• Isaac Paredes had 25 doubles, a triple, 19 home runs and 76 walks while hitting .238.

Astros Team Props

Giants vs. Astros Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Houston Astros.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Houston Astros

San Francisco Giants