Dodgers vs. Guardians Prediction, Odds, Picks - May 28

Clayton Kershaw starts for the Los Angeles Dodgers on Wednesday at Progressive Field against Jose Ramirez and the Cleveland Guardians. First pitch is at 1:10 p.m. ET for the final game of a three-game series. The Dodgers are listed as -175 moneyline favorites for this matchup against the Guardians (+146). Los Angeles is a 1.5-run favorite (at -107 odds). The game's over/under has been set at 9 runs.

Here's everything you need to know from a betting perspective on the Dodgers-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Will Smith smacks a solo homer as Dodgers extend lead over Guardians

Will Smith smacked a solo homer as the Los Angeles Dodgers extend the lead over the Guardians

Dodgers vs. Guardians Game Information & Odds

• When: Wednesday, May 28, 2025 at 1:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: MLB Network, CLEG, and SportsNet LA

Dodgers vs. Guardians Prediction

• Score Prediction: Dodgers 5, Guardians 4
• Total Prediction: Over 9 runs
• Win Probabilities: Dodgers 53%, Guardians 47%

Dodgers vs. Guardians Betting Insights

• The Dodgers have been favorites in 46 games this season and won 30 (65.2%) of those contests.
• Los Angeles has entered 31 games this season favored by -175 or more and is 21-10 in those contests.
• Sportsbooks have implied with the moneyline set for this matchup that the Dodgers have a 63.6% chance to win.
• The Guardians have been victorious in 16, or 48.5%, of the 33 contests they have been chosen as underdogs in this season.
• This year, Cleveland has won one of five games when listed as at least +146 or worse on the moneyline.
• The moneyline set for this matchup implies the Guardians have a 40.7% chance of walking away with the win.

Dodgers Recent Betting Performance

• The Dodgers played as the moneyline favorite for seven of their last 10 games, and went 4-3 in those matchups.
• In their last 10 outings, the Dodgers and their opponents combined to hit the over six times (all 10 of the games had set totals).
• The Dodgers have put together a 4-6-0 record against the spread over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Shohei Ohtani has homered 20 times this season, the highest mark on the Dodgers, while hitting .296 with 35 RBI.
• Of all batters in the majors, Ohtani's home run total places him first, and his RBI tally ranks him 18th.
• Ohtani carries a three-game hitting streak into this matchup. In his last five games he is batting .211 with three home runs, five walks and four RBIs.
• Mookie Betts is hitting .257 with five doubles, a triple, eight home runs and 25 walks.
• Betts is 55th in home runs and 31st in RBI on the year.
• Betts carries a four-game streak with at least one hit into this contest. During his last five outings he is batting .182 with two walks and an RBI.
• Freddie Freeman paces the Dodgers with a .356 batting average.
• Freeman has at least one base hit in three straight games. During his last five outings he is batting .263 with a double, four walks and an RBI.
• Teoscar Hernandez has collected 42 runs batted in to lead his team.
• Hernandez has recorded at least one hit in six games in a row. During his last 10 outings he is hitting .306 with four doubles, a home run, a walk and nine RBIs.

Dodgers Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs in eight of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over seven times.
• The Guardians are 4-6-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez is hitting .311 with 12 doubles, a triple, nine home runs and 17 walks, while getting on base at a rate of .365.
• Ramirez ranks 43rd in home runs and 75th in RBI among all hitters in MLB.
• Ramirez has collected a hit in 20 games in a row. In his last 10 outings he is batting .372 with four doubles, a triple, a walk and three RBIs.
• Steven Kwan has a club-high .314 batting average.
• Kwan ranks 158th among all hitters in MLB in homers, and 141st in RBI.
• Carlos Santana is hitting .243 with five doubles, six home runs and 28 walks.
• Kyle Manzardo paces the Guardians in home runs (10) and runs batted in (28).

Guardians Team Props

Will Smith smacks a solo homer as Dodgers extend lead over Guardians

Will Smith smacked a solo homer as the Los Angeles Dodgers extend the lead over the Guardians

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

Los Angeles Dodgers