Cubs vs. Padres Prediction, Odds, Picks - April 4

The Chicago Cubs and San Diego Padres will play on Friday at Wrigley Field, at 2:20 p.m. ET. Randy Vasquez will start for San Diego, aiming to shut down Ian Happ and company. The favored Cubs have -165 moneyline odds against the underdog Padres, who are listed at +139. Chicago is favored on the run line (-1.5 with +136 odds). The over/under is 7 runs for this game.

Here's everything you need to know from a betting perspective on the Cubs-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Athletics Highlights | MLB on FOX

Check out the best moments between the Chicago Cubs and the Athletics.

Cubs vs. Padres Game Information & Odds

• When: Friday, April 4, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and SDPA

Cubs vs. Padres Prediction

• Score Prediction: Padres 5, Cubs 4
• Total Prediction: Over 7 runs
• Win Probabilities: Cubs 50%, Padres 50%

Cubs vs. Padres Betting Insights

• The Cubs have won both games they've played as favorites this season.
• Chicago has not entered a game this season with shorter moneyline odds than -165.
• The Cubs have a 62.3% chance to win this game based on the implied probability of the moneyline.
• The Padres have won in each of the two contests they have played as underdogs this season.
• San Diego has yet to play a game this season with longer moneyline odds than +139.
• The moneyline set for this matchup implies the Padres have a 41.8% chance of coming away with a victory in the contest.

Cubs Player Insights

• Kyle Tucker has put up a team-best batting average of .324, and paces the Cubs in home runs (four) and runs batted in (11).
• Tucker's home runs place him third in MLB, and he is second in RBI.
• Seiya Suzuki has shown his power as he leads his team with four home runs and 11 runs batted in.
• Including all MLB hitters, Suzuki is third in homers and second in RBI.
• Suzuki carries a four-game streak with at least one hit into this contest. During his last five outings he is batting .391 with a double, four home runs, three walks and 11 RBI.
• Carson Kelly is hitting .417 with a double, a triple, a home run and five walks.
• Dansby Swanson is hitting .222 with three doubles, two home runs and three walks.

Cubs Team Props

Padres Player Insights

• Fernando Tatis Jr. paces the Padres with a .423 batting average.
• Tatis' home run total places him 55th in the big leagues, and he is 34th in RBI.
• Jackson Merrill has been a reliable source of runs this year, leading the lineup with two home runs and eight RBI.
• Merrill ranks 21st overall in homers and eighth in RBI this year.
• Manny Machado has three doubles and two walks while hitting .400.
• Gavin Sheets is batting .444 with two doubles, a home run and a walk.

Padres Team Props

Cubs vs. Athletics Highlights | MLB on FOX

Check out the best moments between the Chicago Cubs and the Athletics.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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