Cubs vs. Padres NL Wild Card Game 2 Prediction, Odds, Picks - October 1

The NL Wild Card Series rolls on Wednesday at 3:08 p.m. ET when the Chicago Cubs host the San Diego Padres live on ABC from Wrigley Field. The Cubs will look to move on to the NLDS while the Padres hope to extend the series with a win. Oddsmakers list the Cubs as -115 favorites on the moneyline, while giving the underdog Padres -105 moneyline odds. San Diego is the run-line favorite (-1.5). The over/under is 6.5 runs for the game (with -113 odds to hit the over and -108 odds to go under).

Check out everything you need to know from a betting perspective on the Cubs-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Cubs vs. Padres Game Information & Odds

• When: Wednesday, October 1, 2025 at 3:08 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: ABC

Cubs vs. Padres Prediction

• Score Prediction: Cubs 5, Padres 4
• Total Prediction: Over 6.5 runs
• Win Probabilities: Cubs 58%, Padres 42%

Cubs vs. Padres Betting Insights

• This season, the Cubs have been favored 117 times and won 75, or 64.1%, of those games.
• Chicago has a record of 73-38, a 65.8% win rate, when favored by -115 or more by sportsbooks this season.
• The moneyline for this contest implies a 53.5% chance of a victory for the Cubs.
• The Padres have won in 35, or 50%, of the 70 contests they have been named as odds-on underdogs this year.
• This season, San Diego has been victorious 31 times in 66 chances when named as an underdog of at least -105 or worse on the moneyline.
• The Padres have an implied victory probability of 51.2% according to the moneyline set for this matchup.

Cubs Recent Betting Performance

• The Cubs were the moneyline favorite in seven of their last 10 games, and finished 5-2 in those matchups.
• In their last 10 matchups -- all had a set run total -- the Cubs and their opponents combined to hit the over on the total six times.
• The Cubs' record against the spread is 6-4-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker has 25 doubles, four triples, 22 home runs and 87 walks while batting .266.
• Among all hitters in baseball, Tucker is 65th in home runs and 77th in RBI.
• Nico Hoerner has a club-leading .297 batting average.
• Hoerner is 264th in home runs and 123rd in RBI on the year.
• Hoerner carries a two-game streak with at least one hit into this contest. In his last five games he is batting .238 with a home run and two RBIs.
• Pete Crow-Armstrong has 37 doubles, four triples, 31 home runs and 29 walks while hitting .247.
• Michael Busch has put his power on display as he paces his team with 34 home runs.

Cubs Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in three of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Padres and their opponents are 4-6-0 in their last 10 games with a total.
• The Padres have six wins against the spread in their last 10 chances.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. is hitting .268 with 27 doubles, two triples, 25 home runs and 89 walks.
• Among all batters in the majors, Tatis ranks 50th in home runs and 84th in RBI.
• Manny Machado has hit 27 home runs with 95 runs batted in, leading the team in both categories.
• Machado is 38th in homers and 20th in RBI among all major league batters this season.
• Luis Arraez has a team-best batting average of .292.
• Ryan O'Hearn is hitting .281 with 21 doubles, a triple, 17 home runs and 58 walks.

Padres Team Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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