Cubs vs. Cardinals Prediction, Odds, Picks - September 27

The St. Louis Cardinals will look to Ivan Herrera for continued success at the plate when they take on Nico Hoerner and the Chicago Cubs on Saturday, in the second game of a three-game series at Wrigley Field. The favored Cubs have -179 moneyline odds to win against the underdog Cardinals, who are listed at +149. Chicago (-1.5) is favored on the run line. The total is 9.5 runs for this game (with -106 odds to hit the over and -114 odds to go under).

Take a look at everything you need from a betting perspective on the Cubs-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Giants Highlights | MLB on FOX

Enjoy the best moments between the San Francisco Giants and the St. Louis Cardinals.

Cubs vs. Cardinals Game Information & Odds

• When: Saturday, September 27, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and FDSMW

Cubs vs. Cardinals Prediction

• Score Prediction: Cubs 5, Cardinals 3
• Total Prediction: Under 9.5 runs
• Win Probabilities: Cubs 58%, Cardinals 42%

Cubs vs. Cardinals Betting Insights

• The Cubs have entered the game as favorites 114 times this season and won 72, or 63.2%, of those games.
• Chicago has a record of 22-9 in games when bookmakers favor them by at least -179 on the moneyline.
• The Cubs have a 64.2% chance to win this game based on the implied probability of the moneyline.
• The Cardinals have been underdogs in 91 games this season and have come away with the win 44 times (48.4%) in those contests.
• St. Louis has a win-loss record of 4-15 when favored by +149 or worse by oddsmakers this year.
• The Cardinals have an implied victory probability of 40.2% according to the moneyline set by sportsbooks for this matchup.

Cubs Recent Betting Performance

• The Cubs were the moneyline favorite in five of their last 10 games, and they went 3-2 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Cubs and their opponents combined to hit the over six times.
• The Cubs have put together a 6-4-0 record against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is batting .270 with 25 doubles, four triples, 22 home runs and 87 walks.
• Of all hitters in the majors, Tucker ranks 65th in homers and 74th in RBI.
• Tucker brings a hitting streak of two games into this game. In his last five games he is hitting .421 with two doubles, a home run, two walks and four RBIs.
• Hoerner has a club-high .300 batting average.
• Hoerner is 264th in home runs in the majors, and 123rd in RBI.
• Pete Crow-Armstrong is batting .245 with 37 doubles, four triples, 30 home runs and 29 walks.
• Crow-Armstrong will look to build on his two-game hitting in this game. During his last five outings he is batting .200 with a home run and three RBIs.
• Seiya Suzuki's 101 runs batted in lead his team.
• Suzuki is riding a five-game hitting streak into this one. During his last five outings he is hitting .286 with a double, three home runs and 10 RBIs.

Cubs Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in eight of their past 10 games and have gone 5-3 in those contests.
• In their last 10 games with a total, the Cardinals and their opponents have failed to hit the over five times.
• The Cardinals are 6-4-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Alec Burleson leads the team in batting average with a high-water mark of .292.
• Among all hitters in the big leagues, Burleson ranks 104th in homers and 88th in RBI.
• Brendan Donovan is hitting .287 with 32 doubles, 10 home runs and 42 walks.
• Donovan is currently 213th in homers and 176th in RBI in the big leagues.
• Herrera is batting .287 with 13 doubles, 19 home runs and 43 walks.
• Lars Nootbaar has 24 doubles, a triple, 13 home runs and 63 walks while batting .235.

Cardinals Team Props

Cardinals vs. Giants Highlights | MLB on FOX

Enjoy the best moments between the San Francisco Giants and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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