Cubs vs. Cardinals Prediction, Odds, Picks - September 26

Pete Crow-Armstrong and Alec Burleson will be among the star attractions when the Chicago Cubs play the St. Louis Cardinals on Friday at 2:20 p.m. ET, at Wrigley Field. The Cardinals are +153 moneyline underdogs for this matchup against the favored Cubs (-184). Chicago is favored on the run line (-1.5 with +104 odds). The over/under is 9 runs for this contest.

Check out everything you need to know from a betting perspective on the Cubs-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Giants Highlights | MLB on FOX

Enjoy the best moments between the San Francisco Giants and the St. Louis Cardinals.

Cubs vs. Cardinals Game Information & Odds

• When: Friday, September 26, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MLB Network, MARQ, and FDSMW

Cubs vs. Cardinals Prediction

• Score Prediction: Cubs 5, Cardinals 4
• Total Prediction: Over 9 runs
• Win Probabilities: Cubs 56%, Cardinals 44%

Cubs vs. Cardinals Betting Insights

• The Cubs have been favorites in 113 games this season and won 71 (62.8%) of those contests.
• This season Chicago has won 20 of its 28 games, or 71.4%, when favored by at least -184 on the moneyline.
• The moneyline for this contest implies a 64.8% chance of a victory for the Cubs.
• The Cardinals have been underdogs in 90 games this season and have come away with the win 44 times (48.9%) in those contests.
• St. Louis has a mark of 4-12 in contests where bookmakers favor it by +153 or worse on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 39.5% chance of walking away with the win.

Cubs Recent Betting Performance

• The Cubs went 3-2 over the five games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings, the Cubs and their opponents combined to go over the run total five times (all 10 games had set totals).
• The Cubs' record against the spread is 6-4-0 over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Nico Hoerner is the Cubs best hitter so far this season, hitting at a team-leading .299 rate along with six homers and 60 RBI.
• In all of the majors, Hoerner ranks 280th in homers and 126th in RBI.
• Crow-Armstrong is batting .244 with 37 doubles, four triples, 29 home runs and 29 walks.
• Crow-Armstrong ranks 31st in home runs and 28th in RBI among all MLB hitters this year.
• Ian Happ has 32 doubles, 23 home runs and 87 walks while batting .242.
• Happ will look to build on his four-game hitting in this game. During his last five outings he is hitting .211 with three doubles, two walks and four RBIs.
• Seiya Suzuki has put up 97 runs batted in to pace his team.
• Suzuki has recorded at least one hit in four games in a row. During his last five outings he is batting .278 with a double, two home runs and six RBIs.

Cubs Team Props

Cardinals Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Cardinals have a record of 6-2.
• The Cardinals and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Cardinals are 7-3-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Burleson leads the Cardinals with a team-high batting average of .293.
• Burleson's home run total places him 103rd in the majors, and he ranks 86th in RBI.
• Burleson carries a nine-game hitting streak into this matchup. In his last 10 outings he is batting .421 with four doubles, a home run, three walks and six RBIs.
• Brendan Donovan is batting .287 with 32 doubles, 10 home runs and 42 walks.
• Donovan is 211th among all hitters in the majors in home runs, and 173rd in RBI.
• Ivan Herrera is hitting .286 with 13 doubles, 19 home runs and 43 walks.
• Lars Nootbaar is batting .237 with 24 doubles, a triple, 13 home runs and 62 walks.

Cardinals Team Props

Cardinals vs. Giants Highlights | MLB on FOX

Enjoy the best moments between the San Francisco Giants and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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