Cardinals vs. Reds Prediction, Odds, Picks - May 1

Elly De La Cruz and the Cincinnati Reds hit the field against Lars Nootbaar and the St. Louis Cardinals on Thursday at 12:40 p.m. ET at Great American Ball Park. The Cardinals are favored in this one, at -118, while the underdog Reds have -102 odds to win. St. Louis (-1.5) is the favorite on the run line. The over/under is 9 runs for the game.

Here is everything you need to know from a betting perspective on the Cardinals-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Reds Game 2 Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and the Cincinnati Reds Game 2.

Cardinals vs. Reds Game Information & Odds

• When: Thursday, May 1, 2025 at 12:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: FDSOH and FDSMW

Cardinals vs. Reds Prediction

• Score Prediction: Reds 5, Cardinals 4
• Total Prediction: Under 9 runs
• Win Probabilities: Cardinals 53%, Reds 47%

Cardinals vs. Reds Betting Insights

• The Cardinals have been favorites in nine games this season and won four (44.4%) of those contests.
• St. Louis has a record of 3-2 in games when bookmakers favor them by at least -118 on the moneyline.
• The Cardinals have a 54.1% chance to win this game based on the implied probability of the moneyline.
• The Reds have been chosen as underdogs in 15 games this year and have walked away with the win seven times (46.7%) in those games.
• This season, Cincinnati has been victorious six times in 13 chances when named as an underdog of at least -102 or worse on the moneyline.
• The Reds have an implied victory probability of 50.5% according to the moneyline set by oddsmakers for this matchup.

Cardinals Recent Betting Performance

• The Cardinals have a 2-1 record over the three games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings (all had set totals), the Cardinals combined with their opponents to go over the total five times.
• The Cardinals have put together a 4-6-0 record against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• The Cardinals' best power option comes in the form of Nootbaar and his five-homer 18-RBI season, both team highs.
• Including all MLB hitters, Nootbaar is 66th in batting average, 15th in on-base percentage, and 58th in slugging.
• Brendan Donovan's .333 batting average is a team-high mark.
• Of all MLB hitters, Donovan ranks 111th in home runs and 44th in RBI.
• Nolan Arenado is hitting .243 with nine doubles, three home runs and 14 walks.
• Victor Scott II is batting .271 with five doubles, a triple, two home runs and 10 walks.
• Scott has recorded at least one hit in two straight games. During his last five outings he is hitting .250 with a home run, two walks and four RBI.

Cardinals Team Props

Reds Recent Betting Performance

• The Reds have been underdogs once in the past 10 games and won that contest.
• In their last 10 games with a total, the Reds and their opponents are 4-6-0 when it comes to hitting the over.
• The Reds have five wins against the spread in their last 10 chances.

Reds Recent Stats

Reds Player Insights

• De La Cruz leads the Reds with five long balls and runs batted in, driving in 24.
• De La Cruz's home run total puts him 47th in MLB, and he is eighth in RBI.
• De La Cruz carries a 14-game hitting streak into this matchup. In his last 10 games he is batting .368 with a double, a home run, four walks and three RBI.
• TJ Friedl has six doubles, a triple, a home run and 10 walks while hitting .275.
• Friedl ranks 216th in homers and 122nd in RBI among all major league hitters this season.
• Gavin Lux leads the Reds' lineup with a .327 batting average.
• Austin Hays leads the Reds with five home runs.

Reds Team Props

Cardinals vs. Reds Game 2 Highlights | MLB on FOX

Check out the best moments between the St. Louis Cardinals and the Cincinnati Reds Game 2.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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