Cardinals vs. Rays Prediction, Odds, Picks - August 21

Pedro Pages and Chandler Simpson will look to continue their recent offensive production when the St. Louis Cardinals and Tampa Bay Rays take the field at George M. Steinbrenner Field on Thursday, at 7:35 p.m. ET. The favored Cardinals have -120 moneyline odds to win against the underdog Rays, who are listed at -100. St. Louis is the favorite on the run line (-1.5 with +143 odds). An 8.5-run over/under has been listed for this contest.

Here's everything you need to know from a betting perspective on the Cardinals-Rays game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Rays Game Information & Odds

• When: Thursday, August 21, 2025 at 7:35 p.m. ET
• Where: George M. Steinbrenner Field in Tampa, Florida
• How to watch on TV: FDSSUN and FDSMW

Cardinals vs. Rays Prediction

• Score Prediction: Rays 5, Cardinals 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cardinals 54%, Rays 46%

Cardinals vs. Rays Betting Insights

• The Cardinals have been favorites in 57 games this season and won 29 (50.9%) of those contests.
• St. Louis has a record of 25-19 in games when sportsbooks favor them by at least -120 on the moneyline.
• The oddsmakers' moneyline implies a 54.5% chance of a victory for the Cardinals.
• The Rays have been chosen as underdogs in 65 games this year and have walked away with the win 26 times (40%) in those games.
• This season, Tampa Bay has been victorious 20 times in 47 chances when named as an underdog of at least -100 or worse on the moneyline.
• The Rays have an implied victory probability of 50% according to the moneyline set for this matchup.

Cardinals Recent Betting Performance

• The Cardinals were favored on the moneyline for three of their last 10 games, and they finished 1-2 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Cardinals and their opponents combined to hit the over on the total five times.
• The Cardinals are 4-6-0 against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• The Cardinals best hitter so far this season is Alec Burleson, who's hitting at a team-leading .284 rate along with 15 homers and 57 RBI.
• In all of the majors, Burleson is 100th in home runs and 80th in RBI.
• Willson Contreras has hit 17 home runs with 67 RBI. Both are team-highs.
• Contreras is 72nd in home runs and 48th in RBI among all major league batters this year.
• Contreras has three straight games with at least one hit. During his last five outings he is batting .294 with a home run, a walk and two RBIs.
• Masyn Winn is batting .260 with 26 doubles, nine home runs and 31 walks.
• Lars Nootbaar is hitting .240 with 19 doubles, 13 home runs and 48 walks.
• Nootbaar has recorded at least one hit in four straight games. During his last five outings he is hitting .409 with a double and two RBIs.

Cardinals Team Props

Rays Recent Betting Performance

• The Rays have played as underdogs in seven of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Rays and their opponents are 8-2-0 when it comes to hitting the over.
• The Rays have three wins against the spread in their last 10 chances.

Rays Recent Stats

Rays Player Insights

• Junior Caminero leads the Rays in home runs (35) and runs batted in (85).
• Caminero's home run total puts him sixth in MLB, and he is 11th in RBI.
• Yandy Diaz is batting .279 with 22 doubles, a triple, 20 home runs and 40 walks.
• Diaz is 48th in home runs and 31st in RBI among all hitters in the big leagues.
• Brandon Lowe is hitting .269 with 13 doubles, 24 home runs and 29 walks.
• Simpson is batting .299 with 10 doubles, two triples and 16 walks.

Rays Team Props

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