Cardinals vs. Padres Prediction, Odds, Picks - July 24

Brendan Donovan and the St. Louis Cardinals will meet Fernando Tatis Jr. and the San Diego Padres on Thursday at Busch Stadium, at 7:45 p.m. ET. The Cardinals are the favorite in this one, at -158, while the underdog Padres have +133 odds to win. St. Louis is a 1.5-run favorite (at +138 odds). The total is 8 runs for the matchup.

Here is everything you need from a betting perspective on the Cardinals-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Padres Game Information & Odds

• When: Thursday, July 24, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and SDPA

Cardinals vs. Padres Prediction

• Score Prediction: Cardinals 5, Padres 4
• Total Prediction: Over 8 runs
• Win Probabilities: Cardinals 53%, Padres 47%

Cardinals vs. Padres Betting Insights

• The Cardinals have been favorites in 48 games this season and won 26 (54.2%) of those contests.
• St. Louis has a record of 7-3 in games when oddsmakers favor them by at least -158 on the moneyline.
• The Cardinals have a 61.2% chance to win this game based on the implied probability of the moneyline.
• The Padres have won in 24, or 49%, of the 49 contests they have been named as odds-on underdogs this year.
• This season, San Diego has been victorious eight times in 18 chances when named as an underdog of at least +133 or worse on the moneyline.
• The Padres have an implied victory probability of 42.9% according to the moneyline set by sportsbooks for this matchup.

Cardinals Recent Betting Performance

• The Cardinals were favored on the moneyline in seven of their last 10 games, and they finished 3-4 in those matchups.
• In their last 10 matchups, the Cardinals and their opponents combined to hit the over on the run total five times (all 10 games had set totals).
• The Cardinals' record against the spread is 4-6-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Donovan is the Cardinals best hitter so far this season, hitting at a team-leading .292 rate along with eight homers and 39 RBI.
• Among all batters in the majors, Donovan's home run total ranks him 161st, and his RBI tally puts him 121st.
• Alec Burleson is batting .290 with 17 doubles, 12 home runs and 25 walks.
• Burleson ranks 101st in homers and 85th in RBI among all hitters in baseball.
• Nolan Arenado has 15 doubles, a triple, 10 home runs and 26 walks while hitting .241.
• Willson Contreras' 13 home runs and 57 RBI both pace his team.
• Contreras brings a four-game streak with at least one hit into this one. During his last five outings he is batting .333 with three doubles, a home run and two RBIs.

Cardinals Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in six of their past 10 games and won four of those contests.
• The Padres and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Padres have eight wins against the spread in their last 10 chances.

Padres Recent Stats

Padres Player Insights

• Manny Machado leads the Padres in home runs (18), runs batted in (61) and has a team-best batting average of .285.
• Machado's home run total puts him 32nd in the majors, and he ranks 22nd in RBI.
• Tatis has 14 doubles, two triples, 16 home runs and 55 walks while batting .262.
• Among all MLB hitters, Tatis ranks 49th in homers and 93rd in RBI.
• Luis Arraez leads the Padres' lineup with a .285 batting average.
• Xander Bogaerts is hitting .268 with 22 doubles, six home runs and 43 walks.

Padres Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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St. Louis Cardinals

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