Cardinals vs. Giants Prediction, Odds, Picks - September 5

The St. Louis Cardinals and Lars Nootbaar ready for the first of a three-game series against Jung Hoo Lee and the San Francisco Giants on Friday at Busch Stadium. The favored Cardinals have -120 moneyline odds against the underdog Giants, who are listed at -100. San Francisco is favored on the run line (-1.5). An 8.5-run over/under has been set for this contest.

Here's everything you need from a betting perspective on the Cardinals-Giants game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Giants Game Information & Odds

• When: Friday, September 5, 2025 at 8:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and NBCS-BA

Cardinals vs. Giants Prediction

• Score Prediction: Cardinals 6, Giants 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Cardinals 51%, Giants 49%

Cardinals vs. Giants Betting Insights

• The Cardinals have been favorites in 64 games this season and won 33 (51.6%) of those contests.
• St. Louis has a record of 27-22 in games when sportsbooks favor them by at least -120 on the moneyline.
• The moneyline for this contest implies a 54.5% chance of a victory for the Cardinals.
• The Giants have won in 27, or 47.4%, of the 57 contests they have been named as odds-on underdogs this year.
• This season, San Francisco has come away with a win 22 times in 45 chances when named as an underdog of at least -100 or worse on the moneyline.
• The Giants have an implied victory probability of 50% according to the moneyline set for this matchup.

Cardinals Recent Betting Performance

• The Cardinals were the moneyline favorite in six of their last 10 games, and they finished 3-3 in those matchups.
• In their last 10 matchups, the Cardinals and their opponents combined to hit the over five times (all 10 of the games had set totals).
• The Cardinals have gone 5-5-0 against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Masyn Winn is hitting .255 with 27 doubles, nine home runs and 33 walks.
• Among all MLB hitters, Winn is 89th in batting average, 115th in on-base percentage, and 139th in slugging.
• Lars Nootbaar is batting .243 with 22 doubles, a triple, 13 home runs and 55 walks.
• Nootbaar is 144th in home runs and 177th in RBI among all MLB hitters this year.
• Ivan Herrera has 11 doubles, 13 home runs and 34 walks while batting .284.
• Victor Scott II has 14 doubles, a triple, five home runs and 38 walks while hitting .223.

Cardinals Team Props

Giants Recent Betting Performance

• The Giants have played as underdogs in four of their past 10 games and won three of those contests.
• When it comes to hitting the over, the Giants and their opponents are 6-3-1 in their last 10 games with a total.
• Over their last 10 games, the Giants are 9-1-0 against the spread.

Giants Recent Stats

Giants Player Insights

• Rafael Devers leads the Giants with 30 long balls and runs batted in, driving in 97.
• Among all hitters in the majors, Devers' home run total ranks 11th and his RBI tally ranks seventh.
• Devers carries a four-game hitting streak into this matchup. In his last five games he is batting .318 with a double, three home runs, two walks and six RBIs.
• Jung Hoo Lee is batting .262 with 30 doubles, 10 triples, seven home runs and 44 walks.
• Lee is currently 247th in homers and 154th in RBI in the big leagues.
• Willy Adames is hitting .230 with 18 doubles, two triples, 26 home runs and 66 walks.
• Heliot Ramos paces the Giants with a team-leading batting average of .268.

Giants Team Props

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Check out the best moments between the Baltimore Orioles and San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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St. Louis Cardinals

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