Blue Jays vs. Orioles Prediction, Odds, Picks - September 12

The Toronto Blue Jays and George Springer will hit the field against the Baltimore Orioles and Jackson Holliday at Rogers Centre on Friday, with the first pitch at 7:07 p.m. ET. Oddsmakers list the Blue Jays as -135 moneyline favorites, while giving the underdog Orioles +114 moneyline odds to win. Toronto is a 1.5-run favorite (at +154 odds). A 7.5-run total is set in this matchup.

Here is everything you need to know from a betting perspective on the Blue Jays-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. Orioles Game Information & Odds

• When: Friday, September 12, 2025 at 7:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: SNET and MASN2

Blue Jays vs. Orioles Prediction

• Score Prediction: Blue Jays 5, Orioles 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Blue Jays 56%, Orioles 44%

Blue Jays vs. Orioles Betting Insights

• This season, the Blue Jays have won 42 out of the 72 games, or 58.3%, in which they've been favored.
• Toronto has a record of 33-15 in games when sportsbooks favor them by at least -135 on the moneyline.
• The moneyline for this contest implies a 57.4% chance of a victory for the Blue Jays.
• The Orioles have come away with 38 wins in the 81 contests they have been listed as the underdogs in this season.
• Baltimore has a mark of 20-26 in contests where sportsbooks favor it by +114 or worse on the moneyline.
• The moneyline set for this matchup implies the Orioles have a 46.7% chance of walking away with the win.

Blue Jays Recent Betting Performance

• The Blue Jays played as the moneyline favorite in five of their last 10 games, and finished 4-1 in those matchups.
• In their last 10 matchups (all had set totals), the Blue Jays combined with their opponents to go over the run total four times.
• The Blue Jays' ATS record is 7-3-0 over their past 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. has 33 doubles, 23 home runs and 76 walks while hitting .301.
• Of all batters in MLB, Guerrero is 49th in homers and 36th in RBI.
• Springer's 28 home runs are a team-high mark.
• Springer is 21st in home runs and 54th in RBI among all hitters in baseball.
• Ernie Clement is hitting .276 with 29 doubles, two triples, nine home runs and 24 walks.
• Alejandro Kirk is hitting .289 with 17 doubles, 12 home runs and 45 walks.

Blue Jays Team Props

Orioles Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Orioles have a record of 6-2.
• When it comes to hitting the over, the Orioles and their opponents are 2-7-1 in their last 10 games with a total.
• Over their last 10 games, the Orioles are 6-4-0 against the spread.

Orioles Recent Stats

Orioles Player Insights

• The Orioles are led in runs batted in by Gunnar Henderson with a mark of 61, he also leads the team in hitting, posting an average of .270.
• Henderson ranks 110th in home runs and 100th in RBI among all hitters in the big leagues.
• Holliday has put up a team-best 17 home runs.
• Holliday ranks 99th among all batters in the majors in homers, and 129th in RBI.
• Ryan Mountcastle has 18 doubles, five home runs and 14 walks while batting .259.
• Colton Cowser is hitting .206 with 12 doubles, 13 home runs and 22 walks.

Orioles Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Toronto Blue Jays

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