Blue Jays vs. Astros Prediction, Odds, Picks - April 22

George Springer and the Toronto Blue Jays hit the field against Isaac Paredes and the Houston Astros on Tuesday at 8:10 p.m. ET, in the second of a three-game series at Daikin Park. The Blue Jays are the favorite in this one, at -120, while the underdog Astros have +100 odds to upset. Toronto is the favorite on the run line (-1.5 with +143 odds). The over/under is 8 runs for the contest.

Here's everything you need from a betting perspective on the Blue Jays-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. Astros Game Information & Odds

• When: Tuesday, April 22, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and SN1

Blue Jays vs. Astros Prediction

• Score Prediction: Astros 5, Blue Jays 4
• Total Prediction: Over 8 runs
• Win Probabilities: Blue Jays 57%, Astros 43%

Blue Jays vs. Astros Betting Insights

• The Blue Jays have won five of the seven games they've played as favorites this season.
• Toronto is 5-1 this season when entering a game favored by -120 or more on the moneyline.
• The Blue Jays have a 54.5% chance to win this game based on the implied probability of the moneyline.
• The Astros have won in four of the eight contests they have been named as odds-on underdogs this year.
• Houston has a win-loss record of 3-3 when favored by +100 or worse by sportsbooks this year.
• The moneyline set for this matchup implies the Astros have a 50% chance of walking away with the win.

Blue Jays Recent Betting Performance

• The Blue Jays have been named the moneyline favorite by bookmakers only once in the last 10 games, and won that matchup.
• In their last 10 matchups, the Blue Jays and their opponents combined to go over the total six times (all 10 games had set totals).
• The Blue Jays' ATS record is 6-4-0 over their past 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. has six doubles, a home run and 14 walks while batting .291.
• Among all MLB hitters, Guerrero is 39th in batting average, 23rd in on-base percentage, and 89th in slugging.
• Bo Joseph Bichette has racked up 13 runs batted in to lead his team.
• Bichette ranks 272nd in homers and 42nd in RBI among all batters in baseball.
• Bichette heads into this matchup looking for his seventh game in a row with a hit. During his last 10 outings he is batting .333 with four doubles, two walks and five RBI.
• Andres Gimenez leads the Blue Jays with three home runs.
• Springer has a club-high .349 batting average.
• Springer takes a two-game streak with at least one hit into this one. In his last five games he is batting .222 with two doubles, three walks and an RBI.

Blue Jays Team Props

Astros Recent Betting Performance

• Over the past 10 games, the Astros have been underdogs twice and split those games 1-1.
• The Astros and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Astros have seven wins against the spread in their last 10 chances.

Astros Recent Stats

Astros Player Insights

• Jeremy Pena has swatted a team-high three long balls.
• Among all hitters in the big leagues, Pena's home run total is 74th and his RBI tally ranks 161st.
• Pena has collected a hit in 12 straight games. In his last 10 games he is hitting .278 with two doubles, a home run, four walks and five RBI.
• Jose Carlos Altuve has hit three home runs while batting .303. Both high-water marks on his team.
• Altuve is currently 74th in homers and 116th in RBI in the big leagues.
• Paredes paces the Astros in home runs (three) and runs batted in (12).
• Yordan Ruben Alvarez has driven in the most runs for the Astros with 12 runs batted in.

Astros Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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